ArticleEuropean child & adolescent psychiatry2016
Interactive effects of BDNF Val66Met genotype and trauma on limbic brain anatomy in childhood.
Article in European child & adolescent psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Socioeconomic factors, brain-derived neurotrophic factor Val66Met polymorphism, and cortical structure in children and adolescents.Scientific reports · 2025Article
- Article
- Association between polygenic risk for Alzheimer's disease and brain structure in children and adults.Alzheimer's research & therapy · 2023Article
- Prolonged Maternal Separation Reduces Anxiety State and Increases Compulsive Burying Activity in the Offspring of BALB/c Mice.Journal of personalized medicine · 2022Article
- Ventromedial and insular cortical volume moderates the relationship between BDNF Val66Met and threat sensitivity.Journal of psychiatric research · 2021Article
- Influence ofFrontiers in behavioral neuroscience · 2021Article
- Effects of BDNF Val66Met polymorphisms on brain structures and behaviors in adolescents with conduct disorder.European child & adolescent psychiatry · 2020Article
- The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders.The American journal of psychiatry · 2020Review
- Influence of childhood trauma and brain-derived neurotrophic factor Val66Met polymorphism on posttraumatic stress symptoms and cortical thickness.Scientific reports · 2019Article
- The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans.Journal of affective disorders · 2018Article
- Neurodevelopmental consequences of pediatric cancer and its treatment: applying an early adversity framework to understanding cognitive, behavioral, and emotional outcomes.Neuropsychology review · 2018Review
- The BDNF ValBehavioural brain research · 2017Article
- Amygdala responses to salient social cues vary with oxytocin receptor genotype in youth.Neuropsychologia · 2015Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Childhood trauma is a major precipitating factor in psychiatric disease. Emerging data suggest that stress susceptibility is genetically determined, and that risk is mediated by changes in limbic brain circuitry. There is a need to identify markers of disease vulnerability, and it is critical that these markers be investigated in childhood and adolescence, a time when neural networks are particularly malleable and when psychiatric disorders frequently emerge. In this preliminary study, we evaluated whether a common variant in the brain-derived neurotrophic factor (BDNF) gene (Val66Met; rs6265) interacts with childhood trauma to predict limbic gray matter volume in a sample of 55 youth high in sociodemographic risk. We found trauma-by-BDNF interactions in the right subcallosal area and right hippocampus, wherein BDNF-related gray matter changes were evident in youth without histories of trauma. In youth without trauma exposure, lower hippocampal volume was related to higher symptoms of anxiety. These data provide preliminary evidence for a contribution of a common BDNF gene variant to the neural correlates of childhood trauma among high-risk urban youth. Altered limbic structure in early life may lay the foundation for longer term patterns of neural dysfunction, and hold implications for understanding the psychiatric and psychobiological consequences of traumatic stress on the developing brain.
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