ArticleCritical care (London, England)2015
Pre-existing atrial fibrillation and risk of arterial thromboembolism and death in intensive care unit patients: a population-based cohort study.
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 15 citations in OpenAlex.
- Evaluation of the effect of empagliflozin on prevention of atrial fibrillation after coronary artery bypass grafting: a double-blind, randomized, placebo-controlled trial.Naunyn-Schmiedeberg's archives of pharmacology · 2024Trial
- Usefulness of Blood-Urea-Nitrogen to Serum Albumin Ratio for In-hospital Mortality Predictions in Atrial Fibrillation Patients Admitted to the Intensive Care Unit: A Retrospective Analysis From MIMIC-IV Database.Reviews in cardiovascular medicine · 2025Article
- Joint effect of atrial fibrillation and obesity on mortality in critically ill patients.Diabetology & metabolic syndrome · 2024Article
- Impact of New-Onset Atrial Fibrillation on Mortality in Critically Ill Patients.Clinical epidemiology · 2024Article
- SARS-CoV-2 Positivity in Ambulatory Symptomatic Patients Is Not Associated With Increased Venous or Arterial Thrombotic Events in the Subsequent 30 Days.The Journal of emergency medicine · 2022Article
- Clinical Outcome of Hospitalized COVID-19 Patients with History of Atrial Fibrillation.Medicina (Kaunas, Lithuania) · 2022Article
- Applicability of stroke volume variation in patients of a general intensive care unit: a longitudinal observational study.Journal of clinical monitoring and computing · 2017Observational
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPre-existing atrial fibrillation (AF) may worsen prognosis in patients admitted to the intensive care unit (ICU).
methodsIn a cohort study (2005-2011) including all patients with first-time ICU admissions in Denmark (n=57,110), we compared patients with and without pre-existing AF and estimated absolute risks and relative risks (RRs) of arterial thromboembolism and death within 30 days and 365 days following admission, using Kaplan-Meier methods and multivariate regression analyses. We analysed the prognostic impact of AF within strata of patient age, sex, coexisting cardiac diseases, and ICU therapies.
resultsAmong ICU patients, 5065 (9%) had pre-existing AF. Compared with patients without AF, those with AF were older (median age 75 vs. 62 years) and had more comorbidity. The risk of arterial thromboembolism was 2.8% in patients with AF and 2.0% in non-AF patients at 30 days, and 4.3% and 2.9%, respectively, at 365 days. Corresponding RRs were 1.41 crude and 1.14 (95% confidence interval [CI] 0.93-1.40) adjusted at 30 days, and 1.50 crude and 1.20 (95% CI 1.02-1.41) adjusted at 365 days. Thirty-day mortality was 27% in patients with pre-existing AF and 16% in non-AF patients (crude RR 1.67, adjusted RR 1.04, 95% CI 0.99-1.10). Corresponding mortality estimates at 365 days were 40.9% and 25.4%, respectively (crude RR 1.61, adjusted RR 1.03, 95% CI 1.00-1.07). In stratified analyses, pre-existing AF increased mortality in ICU patients aged <55 years (adjusted RR at 30 days 1.73, 95% CI 1.29-2.32; adjusted RR at 365 days 1.34, 95% CI 1.06-1.69) and in ICU patients treated with mechanical ventilation (adjusted RR at 30 days 1.12, 95% CI 1.05-1.20, adjusted RR at 365 days 1.09, 95% CI: 1.04-1.15). Analyses stratified by sex and coexisting cardiac diseases yielded adjusted RRs close to 1.
conclusionsIn ICU patients, pre-existing AF was associated with modestly increased risk of arterial thromboembolism when adjusted for the substantially higher age and comorbidity levels in patients with AF, whereas there was no overall association with mortality. In ICU patients aged <55 years and in those treated with mechanical ventilation, AF predicted increased mortality.
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