ReviewBMC infectious diseases2015
Emerging trends and persistent challenges in the management of adult syphilis.
Review in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Tolerability of IM penicillin G benzathine diluted or not with local anesthetics, or different gauge needles for syphilis treatment: a randomized clinical trial.BMC infectious diseases · 2019Trial
- Research of Combined ES-BP Model in Predicting Syphilis Incidence 1982-2020 in Mainland China.Iranian journal of public health · 2023Article
- Otosyphilis.Open forum infectious diseases · 2023Article
- Point-of-Care Diagnostics for Diagnosis of Active Syphilis Infection: Needs, Challenges and the Way Forward.International journal of environmental research and public health · 2022Article
- Mathematical analysis and optimal control interventions for sex structured syphilis model with three stages of infection and loss of immunity.Advances in difference equations · 2021Article
- Neurosyphilis Mimicking Autoimmune Encephalitis: A Case Report and Review of the Literature.Clinical neuropsychiatry · 2020Article
- Is repeated retreatment necessary for HIV-negative serofast early syphilis patients?Experimental and therapeutic medicine · 2020Article
- Frequency and Characteristics of Biological False-Positive Test Results for Syphilis Reported in Florida and New York City, USA, 2013 to 2017.Journal of clinical microbiology · 2019Article
- [Evolution of treatment of syphilis through history].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018Review
- Treatment Outcomes of Brazilian Inmates withThe American journal of tropical medicine and hygiene · 2018Article
- An evaluation of the SD Bioline HIV/syphilis duo test.International journal of STD & AIDS · 2018Article
- Syphilis.Nature reviews. Disease primers · 2017Review
- Article
- Laboratory Diagnosis of Central Nervous System Infection.Current infectious disease reports · 2016Review
- Global challenges in human immunodeficiency virus and syphilis coinfection among men who have sex with men.Expert review of anti-infective therapy · 2016Review
- Challenges to the management of curable sexually transmitted infections.BMC infectious diseases · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
There are an estimated 10.6 million incident cases of syphilis worldwide each year. We highlight some persistent challenges and emerging trends in the clinical management of syphilis with a particular focus on therapy, serology, diagnostics, and prevention. Decades after the introduction of penicillin, the optimal management of early syphilis continues to be a controversial topic, particularly in the setting of HIV co-infection. Similarly, the need for routine lumbar puncture in HIV co-infected asymptomatic persons is an unanswered question. Despite advances in both automation and point-of-care diagnostics, we continue to rely on indirect measures of disease activity to manage this infection. As syphilis rates in some populations continue to rise, novel and effective prevention strategies are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.