SynthesisBMC ophthalmology2015
Meta-analysis of selective laser trabeculoplasty versus topical medication in the treatment of open-angle glaucoma.
Synthesis in BMC ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions: A Meta-Analysis.JAMA network open · 2024Pooled it
- Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.Lancet (London, England) · 2019Trial
- Initial intraocular pressure reduction by mono- versus multi-therapy in patients with open-angle glaucoma: results from the Glaucoma Intensive Treatment Study.Acta ophthalmologica · 2018Trial
- Real-world outcomes of selective laser trabeculoplasty and medical treatment in primary open-angle glaucoma and ocular hypertension.BMJ open ophthalmology · 2025Article
- Cost-effectiveness of selective laser trabeculoplasty as a replacement for hypotensive eye drops in the Brazilian public health system.Clinics (Sao Paulo, Brazil) · 2025Article
- Selective Laser Trabeculoplasty and Outcomes of Subsequent Phacoemulsification Combined with Kahook Dual Blade Goniotomy.Ophthalmology and therapy · 2022Article
- A Review of Selective Laser Trabeculoplasty: "The Hype Is Real".Journal of clinical medicine · 2022Review
- Impact of Short-Term Topical Steroid Therapy on Selective Laser Trabeculoplasty Efficacy.Journal of clinical medicine · 2021Article
- Intraocular pressure-lowering effects of ripasudil, a rho-kinase inhibitor, and selective laser trabeculoplasty as adjuvant therapy in patients with uncontrolled glaucoma.International ophthalmology · 2021Article
- Trends in Glaucoma Surgeries Performed by Glaucoma Subspecialists versus Nonsubspecialists on Medicare Beneficiaries from 2008 through 2016.Ophthalmology · 2021Observational
- Influence of Selective Laser Trabeculoplasty (SLT) on the iStent inject® outcomes.BMC ophthalmology · 2020Article
- Treatment choices for newly diagnosed primary open angle and ocular hypertension patients.Eye (London, England) · 2020Review
- Minimally Invasive Surgery in Mild-to-Moderate Glaucoma Patients in Italy: Is It Time to Change?Clinical ophthalmology (Auckland, N.Z.) · 2020Review
- Efficacy and safety of micropulse laser trabeculoplasty for primary open angle glaucoma.International journal of ophthalmology · 2019Article
- A cost minimisation analysis comparing iStent accompanying cataract surgery and selective laser trabeculoplasty versus topical glaucoma medications in a public healthcare setting in New Zealand.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Article
- A Review of the Clinical Usefulness of Selective Laser Trabeculoplasty in Exfoliative Glaucoma.Advances in therapy · 2018Review
- Selective laser trabeculoplasty: past, present, and future.Eye (London, England) · 2018Review
- Quality of life in glaucoma patients after selective laser trabeculoplasty.International journal of ophthalmology · 2017Article
- Selective laser trabeculoplasty in pseudophakic and phakic eyes: a prospective study.International journal of ophthalmology · 2017Article
- Where does selective laser trabeculoplasty stand now? A review.Eye and vision (London, England) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to examine possible differences in clinical outcomes between selective laser trabeculoplasty (SLT) and topical medication in the treatment of open-angle glaucoma.
methodsPertinent prospective comparative controlled trials comparing SLT with medication were selected through extensive searches of the PubMed, Embase, Web of Science, Chinese Biomedicine Database, and the Cochrane Controlled Trials Register database from their inception up to March 2014. Efficacy estimates were measured by their weighted mean difference (WMD) to calculate the intraocular pressure reduction (IOPR) from baseline to endpoint and by the odds ratio (OR) to determine success rates.
resultsFive prospective studies, which met the predefined criteria, were included in the meta-analysis. Four studies were randomized clinical trials and one study was a prospective non-randomized clinical trial. There were a total of 492 eyes of 366 patients with open-angle glaucoma. Four studies involving 325 eyes compared SLT with medication in terms of the IOPR. The WMD of the IOPR from the baseline was 0.6 (95 % confidence intervals: -0.24,1.43) when comparing SLT with medication. No statistical heterogeneity was observed between studies (χ2 = 1.30, P = 0.75, I(2) = 0.0 %). All five studies reported success rates, with a pooled OR of 0.84 (95 % confidence intervals: 0.42, 1.68), which was not statistically significant. No statistical heterogeneity was observed between studies (χ2 = 5.98, P = 0.200, I(2) = 33.1 %). Subgroup and sensitivity analysis confirmed the high stability of the meta-analysis results.
conclusionsBoth SLT and topical medication demonstrate similar success rates and effectiveness in lowering intraocular pressure in patients with open-angle glaucoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.