ArticleZeitschrift fur Gerontologie und Geriatrie2016
DEL-FINE: a new tool for assessing the delirogenic properties of drugs of relevance for European pharmacotherapy.
Article in Zeitschrift fur Gerontologie und Geriatrie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 14 citations in OpenAlex.
- Development and validation of a new drug-focused predictive risk score for postoperative delirium in orthopaedic and trauma surgery patients.BMC geriatrics · 2024Observational
- Current use of anticholinergic medications in a large naturalistic sample of psychiatric patients.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Polypharmacy in palliative care-COPD and multimorbidity : A case report.Wiener medizinische Wochenschrift (1946) · 2018Article
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Authors and funding
11 authors at 6 institutions in 5 countries.
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Abstract
This article presents a list of potentially delirogenic properties of drugs that are currently of relevance to drug therapy in Europe, which was created through a Delphi process including experts from professions relevant to diagnosis and treatment of delirium. The Diagnostic and Statistical Manual of Mental Disorders 5 (DSM 5) defines delirium as a disturbance in attention, awareness and cognition that develops over a short period of time and fluctuates. Possible causes of delirium are manifold: usually delirium is considered to develop in a multifactorial way, caused by inalterable parameters, such as advanced age and pre-existing cognitive impairment and precipitated by modifiable parameters, such as the use of certain drugs or substance withdrawal. Delirium is a serious condition with a pronounced impact on morbidity, mortality and costs to the healthcare system. Circumstances and drugs that might precipitate or worsen delirium should therefore be avoided whenever possible. A list of drugs that might have a detrimental influence on the emergence and duration of delirium has been created using the terms "delirogenity" and "delirogenic" to describe the potential of a drug or withdrawal to cause or worsen delirium. The results are novel and noteworthy, as their focus is on substances relevant to European pharmacotherapy. Furthermore, they represent a methodical consensus from a group of experts of a wide variety of professions relevant to the prevention, diagnosis and treatment of delirium, such as nursing, pharmacy, pharmacology, surgical and internal medicine, neurology, psychiatry, intensive care and medicine, with working, teaching and scientific experience in several European countries practicing both in primary and secondary care.
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