ArticleDysphagia2015
The Physiologic Impact of Unilateral Recurrent Laryngeal Nerve (RLN) Lesion on Infant Oropharyngeal and Esophageal Performance.
Article in Dysphagia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 35 citations in OpenAlex.
- Effect of Chin-down-plus-larynx-tightening maneuver on swallowing function after minimally invasive esophagectomy: A randomized controlled trail.Cancer medicine · 2020Trial
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- Marmoset (Callithrix jacchus) Swallowing Physiology: Novel Dysphagia Model Across Lifespan.Integrative and comparative biology · 2026Article
- Longitudinal Changes in Aerodigestive Responses to Varying Nipple Properties in Infant Pigs.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- Mapping research trends regarding the mechanism of dysphagia from 1993 to 2023: a bibliometrics study and visualization analysis.Frontiers in neurology · 2024Review
- Exploring the interaction of viscosity and nipple design on feeding performance in an infant pig model.Journal of texture studies · 2023Article
- The effect of stiffness and hole size on nipple compression in infant suckling.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- Article
- Article
- Swallow Safety is Determined by Bolus Volume During Infant Feeding in an Animal Model.Dysphagia · 2021Article
- Pathophysiology of aspiration in a unilateral SLN lesion model using quantitative analysis of VFSS.International journal of pediatric otorhinolaryngology · 2021Article
- Muscle activity and kinematics show different responses to recurrent laryngeal nerve lesion in mammal swallowing.Journal of neurophysiology · 2020Article
- Article
- Effects of Superior Laryngeal Nerve Lesion on Kinematics of Swallowing and Airway Protection in an Infant Pig Model.Dysphagia · 2020Article
- Article
- The effect of preterm birth, recurrent laryngeal nerve lesion, and postnatal maturation on hyoid and thyroid movements, and their coordination in infant feeding.Journal of biomechanics · 2020Article
- Reduced Coordination of Hyolaryngeal Elevation and Bolus Movement in a Pig Model of Preterm Infant Swallowing.Dysphagia · 2020Article
- Recurrent laryngeal nerve transection in mice results in translational upper airway dysfunction.The Journal of comparative neurology · 2020Article
- Chin-down-plus-larynx-tightening maneuver improves choking cough after esophageal cancer surgery.Annals of translational medicine · 2019Article
- Preterm birth disrupts the development of feeding and breathing coordination.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Recurrent laryngeal nerve (RLN) injury in neonates, a complication of patent ductus arteriosus corrective surgery, leads to aspiration and swallowing complications. Severity of symptoms and prognosis for recovery are variable. We transected the RLN unilaterally in an infant mammalian animal model to characterize the degree and variability of dysphagia in a controlled experimental setting. We tested the hypotheses that (1) both airway protection and esophageal function would be compromised by lesion, (2) given our design, variability between multiple post-lesion trials would be minimal, and (3) variability among individuals would be minimal. Individuals' swallowing performance was assessed pre- and post-lesion using high speed VFSS. Aspiration was assessed using the Infant Mammalian Penetration-Aspiration Scale (IMPAS). Esophageal function was assessed using two measures devised for this study. Our results indicate that RLN lesion leads to increased frequency of aspiration, and increased esophageal dysfunction, with significant variation in these basic patterns at all levels. On average, aspiration worsened with time post-lesion. Within a single feeding sequence, the distribution of unsafe swallows varied. Individuals changed post-lesion either by increasing average IMPAS score, or by increasing variation in IMPAS score. Unilateral RLN transection resulted in dysphagia with both compromised airway protection and esophageal function. Despite consistent, experimentally controlled injury, significant variation in response to lesion remained. Aspiration following RLN lesion was due to more than unilateral vocal fold paralysis. We suggest that neurological variation underlies this pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.