ArticleAnatomical record (Hoboken, N.J. : 2007)2015
Elastin Cables Define the Axial Connective Tissue System in the Murine Lung.
Article in Anatomical record (Hoboken, N.J. : 2007), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Review
- Evolving topological order in the postnatal visceral pleura.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Stochastic simulations of self-organized elastogenesis in the developing lung.PLoS computational biology · 2023Article
- Discoidin domain receptor-2 enhances secondary alveolar septation in mice by activating integrins and modifying focal adhesions.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Acinar micromechanics in health and lung injury: what we have learned from quantitative morphology.Frontiers in physiology · 2023Review
- Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts.Development (Cambridge, England) · 2022Article
- Article
- Implications of microscale lung damage for COVID-19 pulmonary ventilation dynamics: A narrative review.Life sciences · 2021Review
- Second harmonic generation imaging of collagen scaffolds within the alveolar ducts of healthy and emphysematous mouse lungs.Histochemistry and cell biology · 2021Article
- Bioengineering the Blood-gas Barrier.Comprehensive Physiology · 2020Review
- Elastin in lung development and disease pathogenesis.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Matrix biomechanics and dynamics in pulmonary fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Neuropilin-1 and platelet-derived growth factor receptors cooperatively regulate intermediate filaments and mesenchymal cell migration during alveolar septation.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Functional Mechanics of a Pectin-Based Pleural Sealant after Lung Injury.Tissue engineering. Part A · 2018Article
- Pressure-decay testing of pleural air leaks in intact murine lungs: evidence for peripheral airway regulation.Physiological reports · 2018Article
- Extracellular Assembly of the Elastin Cable Line Element in the Developing Lung.Anatomical record (Hoboken, N.J. : 2007) · 2017Article
- Deformation-induced transitional myofibroblasts contribute to compensatory lung growth.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Structural and functional evidence for the scaffolding effect of alveolar blood vessels.Experimental lung researchArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The axial connective tissue system is a fiber continuum of the lung that maintains alveolar surface area during changes in lung volume. Although the molecular anatomy of the axial system remains undefined, the fiber continuum of the lung is central to contemporary models of lung micromechanics and alveolar regeneration. To provide a detailed molecular structure of the axial connective tissue system, we examined the extracellular matrix of murine lungs. The lungs were decellularized using a 24 hr detergent treatment protocol. Systematic evaluation of the decellularized lungs demonstrated no residual cellular debris; morphometry demonstrated a mean 39 ± 7% reduction in lung dimensions. Scanning electron microscopy (SEM) demonstrated an intact structural hierarchy within the decellularized lung. Light, fluorescence, and SEM of precision-cut lung slices demonstrated that alveolar duct structure was defined by a cable line element encased in basement membrane. The cable line element arose in the distal airways, passed through septal tips and inserted into neighboring blood vessels and visceral pleura. The ropelike appearance, collagenase resistance and anti-elastin immunostaining indicated that the cable was an elastin macromolecule. Our results indicate that the helical line element of the axial connective tissue system is composed of an elastin cable that not only defines the structure of the alveolar duct, but also integrates the axial connective tissue system into visceral pleura and peripheral blood vessels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.