ArticleBMC women's health2015
Does obesity have detrimental effects on IVF treatment outcomes?
Article in BMC women's health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Effect of weight loss before in vitro fertilization in women with obesity or overweight and infertility: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- The correlation between raised body mass index and assisted reproductive treatment outcomes: a systematic review and meta-analysis of the evidence.Reproductive health · 2018Pooled it
- Double Dosing Levonorgestrel-Based Emergency Contraception for Individuals With Obesity: A Randomized Controlled Trial.Obstetrics and gynecology · 2022Trial
- Characterization of infertile couples and outcomes of their first in vitro fertilization cycle at public fertility centers in Northern and Central Portugal: a five-year cohort study.JBRA assisted reproduction · 2025Observational
- Review
- Predicting factors of ovarian responses in infertile women with polycystic ovary syndrome undergoing IVF/ICSI.Journal of assisted reproduction and genetics · 2025Article
- The management of slow ovarian response in PCOS patients and its impact on clinical pregnancy outcomes.Frontiers in endocrinology · 2025Article
- The PPOS protocol mitigates the detrimental effects of high BMI on embryo and clinical pregnancy outcomes.Reproductive biology and endocrinology : RB&E · 2024Article
- Endometrium development patterns and BMI groups amongFrontiers in endocrinology · 2024Article
- Does body mass index compromise assisted reproductive technique outcomes? A cross-sectional study.International journal of reproductive biomedicine · 2023Article
- A prediction model for high ovarian response in the GnRH antagonist protocol.Frontiers in endocrinology · 2023Article
- Embryonic Development in Relation to Maternal Obesity Does Not Affect Pregnancy Outcomes in FET Cycles.Healthcare (Basel, Switzerland) · 2022Article
- Poor Ovarian Response to Gonadotrophins in PCOS Women after Laparoscopic Ovarian Drilling.Medicina (Kaunas, Lithuania) · 2022Article
- TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids.Reproductive biology and endocrinology : RB&E · 2021Article
- Overweight and obesity significantly reduce pregnancy, implantation, and live birth rates in women undergoing In Vitro Fertilization procedures.JBRA assisted reproduction · 2021Article
- Can Ratios Between Prognostic Factors Predict the Clinical Pregnancy Rate in an IVF/ICSI Program with a GnRH Agonist-FSH/hMG Protocol? An Assessment of 2421 Embryo Transfers, and a Review of the Literature.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Impact of Women Obesity and Obesity Severity on Live Birth Rate after In Vitro Fertilization.Journal of clinical medicine · 2020Article
- Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer.PloS one · 2020Article
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Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate the influence of body mass index (BMI) on the in vitro fertilization (IVF) treatment outcomes in a cohort of women undergoing their first IVF, using an intracytoplasmic sperm injection (ICSI).
methodsThis retrospective cohort study included 298 cycles from women younger than 38 years old undergoing IVF-ICSI at a university infertility clinic. The treatment cycles were divided into three groups according to the BMI of the women involved: normal weight (18.5 ≤ BMI < 25 kg/m(2), 164 cycles), overweight (25 ≤ BMI < 30 kg/m(2), 70 cycles), and obese (BMI ≥ 30 kg/m(2), 64 cycles). The underweight women (BMI < 18.5 kg/m(2)) were not included in the analysis due to small sample size (n = 22). The patient characteristics and IVF-ICSI treatment outcomes were compared between the BMI groups.
resultsThe total gonadotropin dose (p <0.001) and duration of stimulation (p = 0.008) were significantly higher in the obese group when compared to the normal BMI group. There were no significant differences across the BMI categories for the other IVF-ICSI cycle outcomes measured, including the number of retrieved oocytes, mature oocytes, embryos suitable for transfer, proportion of oocytes fertilized, and cycle cancellation rates (p >0.05 for each). Additionally, clinical pregnancy, spontaneous abortion, and the ongoing pregnancy rates per transfer were found to be comparable between the normal weight, overweight, and obese women (p >0.05 for each).
conclusionObese women might require a significantly higher dose of gonadotropins and longer stimulation durations, without greatly affecting the pregnancy outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.