ArticleScientific reports2015
Mitochondrial Haplotypes Influence Metabolic Traits in Porcine Transmitochondrial Cybrids.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- The need to understand the underlying mechanisms associated with mitochondrial therapies in assisted reproduction before further clinical trials are performed.Human reproduction (Oxford, England) · 2026Review
- The nuclear and mitochondrial genomes need to tango. How is their dance synchronized during development?NAR molecular medicine · 2026Article
- Nuclear transfer leads to aberrant cell cycle regulation and translation, as determined by gene expression, and selection of mitochondrial DNA in porcine blastocysts.NAR molecular medicine · 2024Article
- Mitochondrial DNA D-loop SNPs unveil molecular signatures of milk production variation in Murrah buffalo.Molecular biology reports · 2024Article
- Association analysis of mitochondrial genome polymorphisms with backfat thickness in pigs.Animal biotechnology · 2023Article
- The role of mtDNA in oocyte quality and embryo development.Molecular reproduction and development · 2023Review
- Recovery of mitogenomes from whole genome sequences to infer maternal diversity in 1883 modern taurine and indicine cattle.Scientific reports · 2022Article
- Cybrid Model Supports Mitochondrial Genetic Effect on Pig Litter Size.Frontiers in genetics · 2020Article
- Simple, reliable, and time-efficient colorimetric method for the assessment of mitochondrial function and toxicity.Bosnian journal of basic medical sciences · 2018Article
- Article
- Mitotype Interacts With Diet to Influence Longevity, Fitness, and Mitochondrial Functions in Adult FemaleFrontiers in genetics · 2018Article
- Mitochondrial-nuclear crosstalk, haplotype and copy number variation distinct in muscle fiber type, mitochondrial respiratory and metabolic enzyme activities.Scientific reports · 2017Article
- Mitochondrial haplotypes influence metabolic traits across bovine inter- and intra-species cybrids.Scientific reports · 2017Article
- The relationship between mitochondrial DNA haplotype and the reproductive capacity of domestic pigs (Sus scrofa domesticus).BMC genetics · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In farm animals, mitochondrial DNA mutations exist widely across breeds and individuals. In order to identify differences among mtDNA haplotypes, two porcine transmitochondrial cybrids were generated by fusion of a Lantang pig cell line devoid of mitochondrial DNA with enucleated cytoplasm from either a Large White pig or a Xiang pig harboring potentially divergent mitochondrial haplotypes. These cybrid cells were subjected to mitochondrial genome sequencing, copy number detecting and analysis of biochemical traits including succinate dehydrogenase (SDH) activity, ATP content and susceptibility to reactive oxygen species (ROS). The Lantang and Xiang mitochondrial genomes were highly homologous with only 18 polymorphic sites, and differed radically from the Large White with 201 and 198 mutations respectively. The Large White and Xiang cybrids exhibited similar mtDNA copy numbers and different values among biochemical traits, generated greater ROS production (P < 0.05) and less SDH activity (P < 0.05) and a lesser ATP content (P < 0.05). The results show that functional differences exist between cybrid cells which differ in mitochondrial genomic background. In conclusion, transmitochondrial cybrids provide the first direct evidence on pig biochemical traits linking different mitochondrial genome haplotypes.
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