SynthesisBreast cancer research and treatment2015
The effect of immediate breast reconstruction on the timing of adjuvant chemotherapy: a systematic review.
Synthesis in Breast cancer research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Oncological results in women with wound complications following mastectomy and immediate breast reconstruction: A meta-analysis.International wound journal · 2023Pooled it
- Pooled it
- Targeted Multidisciplinary Continuous Improvement Process Reduces Time to Breast Cancer Surgery with Immediate Reconstruction.Annals of surgical oncology · 2026Article
- Exploring Breast Reconstruction in Late-stage Breast Cancer Patients.Plastic and reconstructive surgery. Global open · 2025Article
- Evaluation of Complications Following Nipple Areola Sparing Mastectomy with Immediate Implant-Based Breast Reconstruction in Patients with Large Ptotic Breasts.World journal of plastic surgery · 2025Article
- Immediate implant-based breast reconstruction following mastectomy is not associated with delays in adjuvant therapy.Frontiers in oncology · 2025Article
- Impact of immediate breast reconstruction on perioperative therapy: insights from a Japanese Nationwide Registry.Breast cancer (Tokyo, Japan) · 2024Article
- Efficacy of breast reconstruction for N2-3M0 stage female breast cancer on breast cancer-specific survival: A population-based propensity score analysis.Cancer medicine · 2023Article
- [Choice of immediate breast reconstructive methods after modified radical mastectomy].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Article
- Article
- Breast reconstruction and quality of life five years after cancer diagnosis: VICAN French National cohort.Breast cancer research and treatment · 2022Article
- Helical tomotherapy for post-mastectomy radiation therapy with or without breast implant: a single institution experience.Clinical and translational radiation oncology · 2022Article
- Predictors of delayed breast reconstruction in the Netherlands: a 5-year follow-up study in stage I-III breast cancer patients.Breast cancer (Tokyo, Japan) · 2022Article
- Surgical Management of Locoregional Recurrence in Breast Cancer.Indian journal of surgical oncology · 2021Review
- Clinical outcomes of patients after nipple-sparing mastectomy and reconstruction based on the expander/implant technique.Surgery today · 2021Review
- Breast Reconstruction in Inflammatory Breast Cancer: An Analysis of Predictors, Trends, and Survival from the National Cancer Database.Plastic and reconstructive surgery. Global open · 2021Article
- Effect of Immediate Breast Reconstruction after Standardized Breast Cancer Surgery on the Quality of Life of Patients: A Prospective Multicenter Study.Journal of healthcare engineering · 2021Article
- Oncologic outcomes after immediate breast reconstruction following mastectomy: comparison of implant and flap using propensity score matching.BMC cancer · 2020Article
- Breast Reconstruction after Mastectomy in Women with Breast Cancer: A Systematic and Meta-Analysis Review.World journal of plastic surgery · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adjuvant chemotherapy is often needed to achieve adequate breast cancer control. The increasing popularity of immediate breast reconstruction (IBR) raises concerns that this procedure may delay the time to adjuvant chemotherapy (TTC), which may negatively impact oncological outcome. The current systematic review aims to investigate this effect. During October 2014, a systematic search for clinical studies was performed in six databases with keywords related to breast reconstruction and chemotherapy. Eligible studies met the following inclusion criteria: (1) research population consisted of women receiving therapeutic mastectomy, (2) comparison of IBR with mastectomy only groups, (3) TTC was clearly presented and mentioned as outcome measure, and (4) original studies only (e.g., cohort study, randomized controlled trial, case-control). Fourteen studies were included, representing 5270 patients who had received adjuvant chemotherapy, of whom 1942 had undergone IBR and 3328 mastectomy only. One study found a significantly shorter mean TTC of 12.6 days after IBR, four studies found a significant delay after IBR averaging 6.6-16.8 days, seven studies found no significant difference in TTC between IBR and mastectomy only, and two studies did not perform statistical analyses for comparison. In studies that measured TTC from surgery, mean TTC varied from 29 to 61 days for IBR and from 21 to 60 days for mastectomy only. This systematic review of the current literature showed that IBR does not necessarily delay the start of adjuvant chemotherapy to a clinically relevant extent, suggesting that in general IBR is a valid option for non-metastatic breast cancer patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.