Evidence map›Paper›PMID 26285247›Full record

GuidelineJournal of the National Comprehensive Cancer Network : JNCCN2015

Cancer-Related Fatigue, Version 2.2015.

Ann M Berger, Kathi Mooney, Amy Alvarez-Perez, William S Breitbart, Kristen M Carpenter, David Cella, Charles Cleeland, Efrat Dotan, Mario A Eisenberger, Carmen P Escalante and 19 more

5 registry-linked trialsOpen access · greenAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Journal of the National Comprehensive Cancer Network : JNCCN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 480 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
480citing papers in PubMed, 23 pooled it
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03644329 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Effect of Resistance Training Variable Manipulation (Intensity and Volume) on Body Composition, Fatigability and Functional Capacity in Postmenopausal Breast Cancer Survivors.

TypeinterventionalSponsorUniversidade Federal do Triangulo MineiroRan2018 to 2019Enrolled80ConditionsBreast Cancer Survivors, PostmenopauseArmsControl group, Lower-load resistance training (LL), Higher-load resistance training (HL), Higher-volume resistance training (HV)
NCT03683004 completednot on this mapstarted 2018, after this paper: background citation

Chemotherapy-Related Changes in Neurocognitive Function and Symptoms in Colorectal Cancer Patients: A Pilot Study

TypeobservationalSponsorUniversity of NebraskaRan2018 to 2020Enrolled40ConditionsColorectal Cancer
NCT05067777 phase2terminatednot on this mapstarted 2022, after this paper: background citation

Massage for Prostate Cancer-Related Fatigue (mPROSTATE)

TypeinterventionalSponsorUniversity of UtahRan2022 to 2025Enrolled28ConditionsProstate CarcinomaArmsSwedish Massage Therapy (SMT), Light Touch (LT) Control, Waitlist Control (WLC)
NCT05333250 phase1 / phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Modafinil to Improve Fatiguability (MODIFY): Modafinil vs. Placebo Vanguard RCT

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2026 to 2028Enrolled40ConditionsCancer-related Cognitive Difficulties, Cancer-related Problem/Condition, FatigueArmsModafinil, Placebo
NCT07072780 nacompletednot on this mapstarted 2023, after this paper: background citation

Effectiveness of a Novel Low-level Laser Therapy Protocol in Managing Breast Cancer-Related Lymphedema

TypeinterventionalSponsorPusan National University HospitalRan2023 to 2024Enrolled46ConditionsBreast CancerArmsLow-Level Laser Therapy (904 nm), Low-Level Laser Therapy (650 nm), Sham Laser Therapy
3 · Its place in the literature

Who cites it

480 citing papers in PubMed, 23 syntheses or guidelines pooled it, 912 citations in OpenAlex.

  1. Pooled it
  2. Cancer-related fatigue during treatment with neoadjuvant and/or adjuvant immune checkpoint inhibitors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  3. Diagnostic predictive models for cancer-related fatigue: current evidence and future directions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  7. Guideline
  8. Guideline
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  15. Effects of exercise on life satisfaction of people diagnosed with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  20. Efficacy and safety of moxibustion on cancer-related fatigue: a systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it

420 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 1 institution in 1 country.

Ann M Berger
Kathi Mooney
Amy Alvarez-Perez
William S Breitbart
Kristen M Carpenter
David Cella
Charles Cleeland
Efrat Dotan
Mario A Eisenberger
Carmen P Escalante
Paul B Jacobsen
Catherine Jankowski
Thomas LeBlanc
Jennifer A Ligibel
Elizabeth Trice Loggers
Belinda Mandrell
Barbara A Murphy
Oxana Palesh
William F Pirl
Steven C Plaxe
Michelle B Riba
Hope S Rugo
Carolina Salvador
Lynne I Wagner
Nina D Wagner-Johnston
Finly J Zachariah
Mary Anne Bergman
Courtney Smith
National comprehensive cancer network
General Department of Preventive Medicine · VN

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Cancer-related fatigue is defined as a distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning. It is one of the most common side effects in patients with cancer. Fatigue has been shown to be a consequence of active treatment, but it may also persist into posttreatment periods. Furthermore, difficulties in end-of-life care can be compounded by fatigue. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cancer-Related Fatigue provide guidance on screening for fatigue and recommendations for interventions based on the stage of treatment. Interventions may include education and counseling, general strategies for the management of fatigue, and specific nonpharmacologic and pharmacologic interventions. Fatigue is a frequently underreported complication in patients with cancer and, when reported, is responsible for reduced quality of life. Therefore, routine screening to identify fatigue is an important component in improving the quality of life for patients living with cancer.

Indexed as

Disease ManagementFatigueHumansNeoplasmsStandard of Care

Identifiers

PMID26285247
PMCPMC5499710
OpenAlexW2177704039

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.