ArticleSleep2016
Sleep-Dependent Potentiation in the Visual System Is at Odds with the Synaptic Homeostasis Hypothesis.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 70 citations in OpenAlex.
- Review
- Memory consolidation during sleep: a facilitator of new learning?Neuropsychologia · 2026Review
- Sleep and experience-dependent visual plasticity in the adult cerebral cortex: an update.Sleep · 2025Article
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- Cholinergic modulation of neural networks supports sequential and complementary roles for NREM and REM states in memory consolidation.PLoS computational biology · 2025Article
- Mechanistic insights into the interaction between epilepsy and sleep.Nature reviews. Neurology · 2025Review
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- Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons.bioRxiv : the preprint server for biology · 2025Article
- REM refines and rescues memory representations: a new theory.Sleep advances : a journal of the Sleep Research Society · 2025Review
- Rapid and cumulative adult plasticity in the mouse visual cortex.Frontiers in neural circuits · 2025Article
- Article
- Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia.Communications biology · 2023Article
- Information maximization explains state-dependent synaptic plasticity and memory reorganization during non-rapid eye movement sleep.PNAS nexus · 2023Article
- Acetylcholine-gated current translates wake neuronal firing rate information into a spike timing-based code in Non-REM sleep, stabilizing neural network dynamics during memory consolidation.PLoS computational biology · 2021Article
- Sleep deprivation results in diverse patterns of synaptic scaling across the Drosophila mushroom bodies.Current biology : CB · 2021Article
- Sleep Loss Drives Brain Region-Specific and Cell Type-Specific Alterations in Ribosome-Associated Transcripts Involved in Synaptic Plasticity and Cellular Timekeeping.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The overfitted brain: Dreams evolved to assist generalization.Patterns (New York, N.Y.) · 2021Review
- Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation.Nature communications · 2021Article
- Sleep Promotes Downward Firing Rate Homeostasis.Neuron · 2021Article
- The Engram's Dark Horse: How Interneurons Regulate State-Dependent Memory Processing and Plasticity.Frontiers in neural circuits · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesTwo commentaries recently published in SLEEP came to very different conclusions regarding how data from a mouse model of sleep-dependent neural plasticity (orientation-specific response potentiation; OSRP) fit with the synaptic homeostasis hypothesis (SHY). To assess whether SHY offers an explanatory mechanism for OSRP, we present new data on how cortical neuron firing rates are modulated as a function of novel sensory experience and subsequent sleep in this model system.
methodsWe carried out longitudinal extracellular recordings of single-neuron activity in the primary visual cortex across a period of novel visual experience and subsequent sleep or sleep deprivation. Spontaneous neuronal firing rates and visual responses were recorded from the same population of visual cortex neurons before control (blank screen) or novel (oriented grating) stimulus presentation, immediately after stimulus presentation, and after a period of subsequent ad lib sleep or sleep deprivation.
resultsFiring rate responses to visual stimuli were unchanged across waking experience, regardless of whether a blank screen or an oriented grating stimulus was presented. Firing rate responses to stimuli of the presented stimulus orientation were selectively enhanced across post-stimulus sleep, but these changes were blocked by sleep deprivation. Neuronal firing increased significantly across bouts of post-stimulus rapid eye movement (REM) sleep and slow wave sleep (SWS), but not across bouts of wake.
conclusionsThe current data suggest that following novel visual experience, potentiation of a subset of V1 synapses occurs across periods of sleep. This finding cannot be explained parsimoniously by SHY.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.