ReviewJournal of molecular biology2015
The Evolution of Aggregative Multicellularity and Cell-Cell Communication in the Dictyostelia.
Review in Journal of molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 134 citations in OpenAlex.
- Review
- Many Cells Make Light Work: Self-Generated Gradients OrganizeCold Spring Harbor perspectives in biology · 2026Review
- Regulation of tRNA expression during the social cycle of the amoeba Dictyostelium discoideum.BMC molecular and cell biology · 2026Article
- Genetic Predisposition Toward Multicellularity in Chlamydomonas reinhardtii.Genome biology and evolution · 2025Article
- Multi-omics analysis of aggregative multicellularity.iScience · 2024Article
- The evolution of multicellularity and cell differentiation symposium: bridging evolutionary cell biology and computational modelling using emerging model systems.Biology open · 2024Review
- Comprehensive characterization of extracellular vesicles produced by environmental (Neff) and clinical (T4) strains ofmSystems · 2024Article
- Group-selection via aggregative propagule-formation enables cooperative multicellularity in an individual based, spatial model.PLoS computational biology · 2024Article
- Evolution of microRNAs in Amoebozoa and implications for the origin of multicellularity.Nucleic acids research · 2024Article
- Copper stress shapes the dynamic behavior of amoebae and their associated bacteria.The ISME journal · 2024Article
- Article
- Review
- Evolution of selfish multicellularity: collective organisation of individual spatio-temporal regulatory strategies.BMC ecology and evolution · 2023Article
- Chemical factors induce aggregative multicellularity in a close unicellular relative of animals.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Development of the dictyostelid Polysphondylium violaceum does not require secreted cAMP.Biology open · 2023Article
- Quantitative models for building and growing fated small cell networks.Interface focus · 2022Review
- Varied solutions to multicellularity: The biophysical and evolutionary consequences of diverse intercellular bonds.Biophysics reviews · 2022Review
- Investigating cell autonomy in microorganisms.Current genetics · 2022Article
- Why have aggregative multicellular organisms stayed simple?Current genetics · 2021Review
- Social selection within aggregative multicellular development drives morphological evolution.Proceedings. Biological sciences · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review, we summarise trends in the evolution of cell-type specialisation and behavioural complexity in the four major groups of Dictyostelia. We describe the cell-cell communication systems that control the developmental programme of D. discoideum, highlighting the central role of cAMP in the regulation of cell movement and cell differentiation. Comparative genomic studies showed that the proteins involved in cAMP signalling are deeply conserved across Dictyostelia and their unicellular amoebozoan ancestors. Comparative functional analysis revealed that cAMP signalling in D. discoideum originated from a second messenger role in amoebozoan encystation. We highlight some molecular changes in cAMP signalling genes that were responsible for the novel roles of cAMP in multicellular development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.