Evidence map›Paper›PMID 26284813›Full record

ArticleNature communications2015

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

M Geoffrey Hayes, Margrit Urbanek, David A Ehrmann, Loren L Armstrong, Ji Young Lee, Ryan Sisk, Tugce Karaderi, Thomas M Barber, Mark I McCarthy, Stephen Franks and 14 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 202 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 11 pooled it
48.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 11 syntheses or guidelines pooled it, 536 citations in OpenAlex.

  1. Pooled it
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  5. New insights into the (epi)genetics of twinning.Human reproduction (Oxford, England) · 2024
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  20. Polymorphism of theLife (Basel, Switzerland) · 2026
    Article

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 20 institutions in 4 countries.

M Geoffrey Hayes1] Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA [2] Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA [3] Department of Anthropology, Northwestern University, Evanston, Illinois 60208, USA.
Margrit Urbanek1] Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA [2] Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
David A EhrmannSection of Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, Illinois 60637, USA.
Loren L ArmstrongDivision of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Ji Young LeeDivision of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Ryan SiskDivision of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Tugce KaraderiWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Thomas M BarberWarwick Medical School, University of Warwick, Warwick CV4 7AL, UK.
Mark I McCarthy1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LE, UK [3] Oxford NIHR Biomedical Research Centre, Churchill Hospital, Headington OX3 7LE, UK.
Stephen FranksInstitute of Reproductive &Developmental Biology, Hammersmith Hospital, Imperial College London, London W12 0NN, UK.
Cecilia M Lindgren1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Corrine K WeltDivision of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah 84112, USA.
Evanthia Diamanti-KandarakisEndocrinology and Metabolism, University of Athens Medical School, Athens 115 27, Greece.
Dimitrios PanidisDivision of Endocrinology and Human Reproduction, 2nd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki 54124, Greece.
Mark O GoodarziDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Ricardo AzzizDepartments of Obstetrics and Gynecology and Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912, USA.
Yi Zhang1] TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA [2] Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Roland G James1] TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA [2] Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Michael OlivierDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78256, USA.
Ahmed H Kissebah1] TOPS Obesity and Metabolic Research Center, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA [2] Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Reproductive Medicine Network
Elisabet Stener-VictorinDepartment of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Richard S LegroDepartment of Obstetrics and Gynecology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
Andrea Dunaif1] Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA [2] Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Northwestern University · USVirginia Commonwealth University · USCentre for Human Genetics · GBMedical College of Wisconsin · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Michigan · USWayne State University · USDuke University · USKarolinska Institutet · SESUNY Upstate Medical University · USThe University of Texas Health Science Center at San Antonio · USUniversity of Alabama at Birmingham · USUniversity of Pittsburgh · USUniversity of Vermont · USYale University · USAristotle University of Thessaloniki · GRAugusta University · USBaylor College of Medicine · USCarolinas Medical Center · USCedars-Sinai Medical Center · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Data Coordination Center for the RMNU10HD055925 · NICHD · YALE UNIVERSITY · PI ZHANG, HEPING · 2007 to 2019
$39.2M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
TRANSGENIC COREP60DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI BELL, GRAEME I · 1985 to 2012
$25.5M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Role of Androgen Excess in Provoking Oxidative Stress in FemalesP50HD044405 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DUNAIF, ANDREA E · 2002 to 2017
$17.2M
Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
PROJECT 3 - Steroid-Metabolic Interactions In the Control of GnRH NeuronsU54HD028934 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI MARSHALL, JOHN C · 1998 to 2013
$16.5M
Translational Research in Polycystic Ovary SyndromeU54HD034449 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI STRAUSS, JEROME F · 1997 to 2012
$15.0M
Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)UL1TR000150 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2012 to 2013
$10.1M
Medical Research Council G0802782Medical Research Council G9710020Medical Research Council MR/M012638/1NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1 TR000150NCATS NIH HHS UL1 TR000430NCRR NIH HHS UL1 RR025758NCRR NIH HHS UL1 RR033184NHLBI NIH HHS R01 HL075079NICHD NIH HHS K24 HD001346NICHD NIH HHS K24 HD01346NICHD NIH HHS P50 HD044405NICHD NIH HHS P50 HD057796NICHD NIH HHS R01 HD029364NICHD NIH HHS R01 HD056510NICHD NIH HHS R01 HD057223NICHD NIH HHS R01 HD057450NICHD NIH HHS R01 HD065029NICHD NIH HHS R01 HD29364NICHD NIH HHS U10 HD027049NICHD NIH HHS U10 HD038992NICHD NIH HHS U10 HD038998NICHD NIH HHS U10 HD039005NICHD NIH HHS U10 HD055925NICHD NIH HHS U10 HD055936NICHD NIH HHS U10 HD055942NICHD NIH HHS U10 HD055944NICHD NIH HHS U10 HD27049NICHD NIH HHS U10 HD38992NICHD NIH HHS U10 HD38998NICHD NIH HHS U10 HD39005NICHD NIH HHS U54 HD028934NICHD NIH HHS U54 HD034449NICHD NIH HHS U54 HD28934NICHD NIH HHS U54 HD34449NIDDK NIH HHS DK20595NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P60 DK020595NIDDK NIH HHS R01 DK065598NIDDK NIH HHS R01 DK071895NIDDK NIH HHS R01 DK65598NIEHS NIH HHS P30 ES013508Wellcome TrustWellcome Trust 086596Wellcome Trust 090532Wellcome Trust 098381
6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating hormone secretion, insulin resistance and developmental exposure to androgens are hypothesized to play a causal role in PCOS. Here we map common genetic susceptibility loci in European ancestry women for the National Institutes of Health PCOS phenotype, which confers the highest risk for metabolic morbidities, as well as reproductive hormone levels. Three loci reach genome-wide significance in the case-control meta-analysis, two novel loci mapping to chr 8p23.1 [Corrected] and chr 11p14.1, and a chr 9q22.32 locus previously found in Chinese PCOS. The same chr 11p14.1 SNP, rs11031006, in the region of the follicle-stimulating hormone B polypeptide (FSHB) gene strongly associates with PCOS diagnosis and luteinizing hormone levels. These findings implicate neuroendocrine changes in disease pathogenesis.

Indexed as

Genome-Wide Association StudyAdolescentAdultCase-Control StudiesFemaleGene Expression RegulationHumansMiddle AgedPolycystic Ovary SyndromePolymorphism, Single NucleotideQuantitative Trait LociWhite PeopleYoung Adult

Identifiers

PMID26284813
PMCPMC4557132
OpenAlexW1128977061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.