Evidence map›Paper›PMID 26284581›Full record

ArticleJournal of cellular physiology2016

Defining Plasma MicroRNAs Associated With Cognitive Impairment In HIV-Infected Patients.

Ferdous Kadri, Andrea LaPlante, Mariacristina De Luca, Lisa Doyle, Cruz Velasco-Gonzalez, Jonathan R Patterson, Patricia E Molina, Steve Nelson, Arnold H Zea, Christopher H Parsons and 1 more

Abstract read
In one paragraph

Article in Journal of cellular physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Neurocognitive Impairment and Associated Genetic Aspects in HIV Infection.Current topics in behavioral neurosciences · 2021
    Article
  8. Review
  9. Observational
  10. Point of care testing for infectious diseases.Clinica chimica acta; international journal of clinical chemistry · 2019
    Review
  11. Article
  12. Article
  13. HIV/neuroAIDS biomarkers.Progress in neurobiology · 2017
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ferdous KadriLSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Andrea LaPlanteLSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Mariacristina De LucaLSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Lisa DoyleLSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Cruz Velasco-GonzalezLSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Jonathan R PattersonLSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Patricia E MolinaDepartment of Physiology, LSU Health Sciences Center, Medical School, New Orleans, Louisiana.
Steve NelsonLSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Arnold H ZeaLSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Christopher H ParsonsLSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.
Francesca PeruzziLSU Health Sciences Center, Medical School, Stanley S. Scott Cancer Center, New Orleans, Louisiana.

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Mentoring Translational Researchers in LouisianaP20GM103501 · NIGMS · LSU HEALTH SCIENCES CENTER · PI OCHOA, AUGUSTO C. · 2012 to 2014
$6.3M
Regulation of the Tumor Microenvironment by KSHVR01CA142362 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PARSONS, CHRISTOPHER H · 2010 to 2014
$1.4M
NCI NIH HHS R01 CA142362NIGMS NIH HHS P20 GM103501NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Human Immunodeficiency Virus (HIV)-infected individuals are at increased risk for developing neurocognitive disorders and depression. These conditions collectively affect more than 50% of people living with HIV/AIDS and adversely impact adherence to HIV therapy. Thus, identification of early markers of neurocognitive impairment could lead to interventions that improve psychosocial functioning and slow or reverse disease progression through improved treatment adherence. Evidence has accumulated for the role and function of microRNAs in normal and pathological conditions. We have optimized a protocol to profile microRNAs in body fluids. Using this methodology, we have profiled plasma microRNA expression for 30 age-matched, HIV-infected (HIV(+) ) patients and identified highly sensitive and specific microRNA signatures distinguishing HIV(+) patients with cognitive impairment from those without cognitive impairment. These results justify follow-on studies to determine whether plasma microRNA signatures can be used as a screening or prognostic tool for HIV(+) patients with neurocognitive impairment. J. Cell. Physiol. 231: 829-836, 2016. © 2015 Wiley Periodicals, Inc.

Indexed as

AdultCognitive DysfunctionDemographyHIV InfectionsHumansMicroRNAsMiddle AgedReal-Time Polymerase Chain ReactionReference StandardsReproducibility of ResultsROC CurveMicroRNAs

Identifiers

PMID26284581
PMCPMC4758906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.