Evidence map›Paper›PMID 26284530›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2016

Using a Multitest Algorithm to Improve the Positive Predictive Value of Rapid HIV Testing and Linkage to HIV Care in Nonclinical HIV Test Sites.

Kevin P Delaney, Jacqueline Rurangirwa, Shelley Facente, Teri Dowling, Mike Janson, Thomas Knoble, Annie Vu, Yunyin W Hu, Peter R Kerndt, Jan King and 1 more

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Time From HIV Infection to Diagnosis in the U.S., 2014-2018.American journal of preventive medicine · 2021
    Article
  3. Differences among diagnostic testing algorithms in the time from HIV diagnosis to care.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2019
    Article
  4. Trends in testing algorithms used to diagnose HIV infection, 2011-2015, United States and 6 dependent areas.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kevin P Delaney*Division of HIV/AIDS Prevention, US Centers for Disease Control and Prevention, Atlanta, GA;†Division of HIV and STD Programs, Department of Public Health, County of Los Angeles, Los Angeles, CA;‡HIV Prevention Section, San Francisco Department of Public Health, San Francisco, CA;§HIV Epidemiology Section, San Francisco Department of Public Health, San Francisco, CA; and‖Department of Public Health, County of Los Angeles, Los Angeles, CA.
Jacqueline Rurangirwa
Shelley Facente
Teri Dowling
Mike Janson
Thomas Knoble
Annie Vu
Yunyin W Hu
Peter R Kerndt
Jan King
Susan Scheer

Funding

PS06-002 Rap Test Algorithm in Non-Trad Test Stes to Improve Linkage to CareU18PS000295 · PS · LOS ANGELES COUNTY HEALTH SERVICES DEPT · PI KING, JAN · 2006 to 2008
$573k
PS06-002 Rap Test Algorithm in Non-Trad Test Stes to Improve Linkage to CareU18PS000292 · PS · SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH · PI DOWLING, TERI · 2006 to 2008
$528k
Intramural CDC HHS CC999999NCHHSTP CDC HHS PS06-002NCHHSTP CDC HHS U18 PS000292NCHHSTP CDC HHS U18 PS000295
6 · The paper itself

Abstract

backgroundUse of a rapid HIV testing algorithm (RTA) in which all tests are conducted within one client appointment could eliminate off-site confirmatory testing and reduce the number of persons not receiving confirmed results.

methodsAn RTA was implemented in 9 sites in Los Angeles and San Francisco; results of testing at these sites were compared with 23 sites conducting rapid HIV testing with off-site confirmation. RTA clients with reactive results on more than 1 rapid test were considered HIV+ and immediately referred for HIV care. The positive predictive values (PPVs) of a single rapid HIV test and the RTA were calculated compared with laboratory-based confirmatory testing. A Poisson risk regression model was used to assess the effect of RTA on the proportion of HIV+ persons linked to HIV care within 90 days of a reactive rapid test.

resultsThe PPV of the RTA was 100% compared with 86.4% for a single rapid test. The time between testing and receipt of RTA results was on average 8 days shorter than laboratory-based confirmatory testing. For risk groups other than men who had sex with men, the RTA increased the probability of being in care within 90 days compared with standard testing practice.

conclusionsThe RTA increased the PPV of rapid testing to 100%, giving providers, clients, and HIV counselors timely information about a client's HIV-positive serostatus. Use of RTA could reduce loss to follow-up between testing positive and confirmation and increase the proportion of HIV-infected persons receiving HIV care.

Indexed as

AlgorithmsBlotting, WesternDelivery of Health CareHIV-1HIV AntibodiesHIV InfectionsHumansImmunoenzyme TechniquesLos AngelesMass ScreeningPatient Care ManagementPredictive Value of TestsReagent Kits, DiagnosticSan FranciscoSerologic TestsTime FactorsHIV AntibodiesReagent Kits, Diagnostic

Identifiers

PMID26284530
PMCPMC4728707

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.