Evidence map›Paper›PMID 26284522›Full record

ArticlePloS one2015

Effect of Common Genetic Variants of Growth Arrest-Specific 6 Gene on Insulin Resistance, Obesity and Type 2 Diabetes in an Asian Population.

Chang-Hsun Hsieh, Ren-Hua Chung, Wen-Jane Lee, Ming-Wei Lin, Lee-Ming Chuang, Thomas Quertermous, Themistocles Assimes, Yi-Jen Hung, Ya-Wen Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Chang-Hsun HsiehDivision of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Ren-Hua ChungDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences National Health Research Institutes, Miaoli Country, Taiwan.
Wen-Jane LeeDepartment of Medical Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Ming-Wei LinInstitute of Public Health, National Yang-Ming University, Taipei, Taiwan, and Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan.
Lee-Ming ChuangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, and Graduate Institute of Preventive Medicine, National Taiwan University School of Public Health, Taipei, Taiwan.
Thomas QuertermousDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of America; Stanford Cardiovascular Institute, Stanford University, Stanford, California, United States of America.
Themistocles AssimesDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of America; Stanford Cardiovascular Institute, Stanford University, Stanford, California, United States of America.
Yi-Jen HungDivision of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Ya-Wen YuDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences National Health Research Institutes, Miaoli Country, Taiwan.
National Health Research Institutes · TWTri-Service General Hospital · TWCardiovascular Institute of the South · USNational Taiwan University Hospital · TWStanford University · USTaichung Veterans General Hospital · TWTaipei Veterans General Hospital · TW

Funding

Molecular Mechanisms of Insulin Resistance Associated LociR01DK107437 · NIDDK · STANFORD UNIVERSITY · PI QUERTERMOUS, THOMAS · 2016 to 2019
$2.2M
NIDDK NIH HHS R01 DK107437
6 · The paper itself

Abstract

objectivesGrowth arrest-specific 6 (Gas6), a vitamin K-dependent protein, has been implicated in systemic inflammation, obesity, and insulin resistance (IR). Data from recent studies suggest that polymorphisms in the Gas6 gene are associated with cardiovascular disorders and type 2 diabetes (T2D). However, the association of Gas6 gene variants with obesity, IR, and T2D development has not been explored. MATERIALS AND

methodsFour common single nucleotide polymorphisms (SNPs) in the Gas6 gene were genotyped in 984 participants from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) family cohort. An insulin suppression test was performed to determine IR based on steady-state plasma glucose (SSPG). Associations between IR indices and obesity, and SNP genotypes, based on previously-reported data for this cohort (Phase I), were analyzed. In the present follow-up study (Phase II), the effects of gene variants of Gas6 on the progression to T2D were explored in individuals who were free of T2D in Phase I. The mean follow-up period for Phase II was 5.7 years.

resultsThe mean age of the study population in Phase I was 49.5 years and 16.7% of individuals developed T2D during follow-up. After adjusting for covariates, three SNPs (rs8191973, rs8197974, and rs7323932) were found to be associated with SSPG levels (p = 0.007, p = 0.03, and p = 0.011, respectively). This association remained significant after multiple testing and showed a significant interaction with physical activity for SNP rs8191973. However, no other significant correlations were observed between Gas6 polymorphisms and other indices of IR or obesity. A specific haplotype, AACG (from rs8191974, rs7323932, rs7331124, and rs8191973), was positively associated with SSPG levels (p = 0.0098). None of the polymorphisms were associated with an increased risk of T2D development.

conclusionsOur results suggest that Gas6 gene variants are associated with IR, although their effects on subsequent progression to T2D were minimal in this prospective Asian cohort.

Indexed as

Polymorphism, Single NucleotideAsian PeopleDiabetes Mellitus, Type 2FemaleGene FrequencyGenetic Predisposition to DiseaseGrowth Arrest-Specific Protein 6HumansInsulin ResistanceIntercellular Signaling Peptides and ProteinsLinkage DisequilibriumMaleMiddle AgedObesityGrowth Arrest-Specific Protein 6Intercellular Signaling Peptides and Proteins

Identifiers

PMID26284522
PMCPMC4540485
OpenAlexW1773960751

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.