ReviewFrontiers in bioengineering and biotechnology2015
CO2 - Intrinsic Product, Essential Substrate, and Regulatory Trigger of Microbial and Mammalian Production Processes.
Review in Frontiers in bioengineering and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- Scale-down bioreactors-comparative analysis of configurations.Bioprocess and biosystems engineering · 2025Review
- Single Cell Protein Production From Ethanol: Model-Based Bioreactor Operation at Industrial Scale.Biotechnology and bioengineering · 2025Article
- Completely noninvasive multi-analyte monitoring system for cell culture processes.Biotechnology letters · 2024Article
- Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023Review
- Low COBiotechnology letters · 2023Article
- Fetal oxygenation in the last weeks of pregnancy evaluated through the umbilical cord blood gas analysis.Frontiers in pediatrics · 2023Article
- COSynthetic and systems biotechnology · 2022Article
- Interplay of carbon dioxide and peroxide metabolism in mammalian cells.The Journal of biological chemistry · 2022Review
- A novel approach to noninvasive monitoring of dissolved carbon dioxide in small-scale cell culture processes.Frontiers in bioengineering and biotechnology · 2022Article
- Toward Best Practices for Controlling Mammalian Cell Culture Environments.Frontiers in cell and developmental biology · 2022Review
- Flexible sensor patch for continuous carbon dioxide monitoring.Frontiers in chemistry · 2022Article
- Recombinant Protein Expression and Purification of N, S1, and RBD of SARS-CoV-2 from Mammalian Cells and Their Potential Applications.Diagnostics (Basel, Switzerland) · 2021Article
- Contact Effect of aAntibiotics (Basel, Switzerland) · 2020Article
- Analysis and effect of conventional flasks in shaking culture of Escherichia coli.AMB Express · 2020Article
- Real-time dissolved carbon dioxide monitoring I: Application of a novel in situ sensor for COBiotechnology and bioengineering · 2020Article
- Real-time dissolved carbon dioxide monitoring II: Surface aeration intensification for efficient COBiotechnology and bioengineering · 2020Article
- COmBio · 2020Article
- A Carbonic Anhydrase Pseudogene Sensitizes SelectJournal of bacteriology · 2019Article
- Influence of Hydrogen Electron Donor, Alkaline pH, and High Nitrate Concentrations on Microbial Denitrification: A Review.International journal of molecular sciences · 2019Review
- Impact of COJournal of bacteriology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon dioxide formation mirrors the final carbon oxidation steps of aerobic metabolism in microbial and mammalian cells. As a consequence, [Formula: see text] dissociation equilibria arise in fermenters by the growing culture. Anaplerotic reactions make use of the abundant [Formula: see text] levels for refueling citric acid cycle demands and for enabling oxaloacetate-derived products. At the same time, CO2 is released manifold in metabolic reactions via decarboxylation activity. The levels of extracellular [Formula: see text] depend on cellular activities and physical constraints such as hydrostatic pressures, aeration, and the efficiency of mixing in large-scale bioreactors. Besides, local [Formula: see text] levels might also act as metabolic inhibitors or transcriptional effectors triggering regulatory events inside the cells. This review gives an overview about fundamental physicochemical properties of [Formula: see text] in microbial and mammalian cultures effecting cellular physiology, production processes, metabolic activity, and transcriptional regulation.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.