Evidence map›Paper›PMID 26284144›Full record

ArticleTheranostics2015

Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy.

Renfa Liu, Lijia Jing, Dong Peng, Yong Li, Jie Tian, Zhifei Dai

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Recent Trends in Biomedical Applications of CuInternational journal of nanomedicine · 2025
    Review
  2. Review
  3. Review
  4. Article
  5. Biomineralized hybrid nanodots for tumor therapyFrontiers in bioengineering and biotechnology · 2022
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Molecular Imaging in Nanotechnology and Theranostics.Molecular imaging and biology · 2017
    Review
  13. Review
  14. Oxidation-Responsive, EuACS omega · 2017
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Renfa Liu1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China;
Lijia Jing1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China; ; 3. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
Dong Peng2. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;
Yong Li3. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China.
Jie Tian2. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;
Zhifei Dai1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy. In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method. The obtained ultrasmall nanoparticles exhibit excellent photothermal effect and photoaoustic activity. Besides, the high loading content of Mn(II) chelates makes the nanoparticles attractive T1 contrast agent in magnetic resonance imaging (MRI). In vivo photoacoustic imaging (PAI) results showed that the nanoparticles could be efficiently accumulated in tumor site in 24 h after systematic administration, which was further validated by MRI tests. The subsequent photothermal therapy of cancer in vivo was achieved without inducing any observed side effects. Therefore, the copper sulfide nanoparticles functionalized with Mn(II) chelate hold great promise as a theranostic nanomedicine for MR/PA dual-modal imaging guided photothermal therapy of cancer.

Indexed as

PhototherapyAnimalsCell Line, TumorCopperFemaleHyperthermia, InducedMagnetic Resonance ImagingManganeseMiceMice, NudeNanoparticlesNeoplasmsPhotoacoustic TechniquesRadiographySulfidesCopperManganeseSulfidesCopper sulfide nanoparticlesMagnatic resonance imagingNanotheranostic agentPhotoacoustic imagingPhotothermal therapy.

Identifiers

PMID26284144
PMCPMC4533097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.