Evidence map›Paper›PMID 26284125›Full record

ArticlePolymer chemistry2015

Design of Thiol- and Light-sensitive Degradable Hydrogels using Michael-type Addition Reactions.

Prathamesh M Kharkar, Kristi L Kiick, April M Kloxin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymer chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
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  10. Review
  11. Redox-Responsive Drug Delivery Systems: A Chemical Perspective.Nanomaterials (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Review
  14. Clickable Biomaterials for Modulating Neuroinflammation.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Prathamesh M KharkarDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
Kristi L KiickDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA ; Department of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA ; Delaware Biotechnology Institute, University of Delaware, Newark, DE 19716, USA.
April M KloxinDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA ; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.

Funding

Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI PATEL, SANDEEP · 2014 to 2018
$5.8M
Molecular Design of Advanced BiomaterialsP20GM103541 · NIGMS · UNIVERSITY OF DELAWARE · PI POLENOVA, TATYANA · 2012 to 2012
$2.1M
NIGMS NIH HHS P20 GM103541NIGMS NIH HHS P30 GM110758
6 · The paper itself

Abstract

Injectable depots that respond to exogenous and endogenous stimuli present an attractive strategy for tunable, patient-specific drug delivery. Here, the design of injectable and multimodal degradable hydrogels that respond to externally applied light and physiological stimuli, specifically aqueous and reducing microenvironments, is reported. Rapid hydrogel formation was achieved using a thiol-maleimide click reaction between multifunctional poly(ethylene glycol) macromers. Hydrogel degradation kinetics in response to externally applied cytocompatible light, reducing conditions, and hydrolysis were characterized, and degradation of the gel was controlled over multiple time scales from seconds to days. Further, tailored release of an encapsulated model cargo, fluorescent nanobeads, was demonstrated.

Identifiers

PMID26284125
PMCPMC4536978

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.