ArticleFrontiers in plant science2015
Binary stress induces an increase in indole alkaloid biosynthesis in Catharanthus roseus.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- UVR8-mediated UV-B signaling and its regulation of horticultural traits: from Arabidopsis to application.Horticulture research · 2026Review
- UV-B and far-red light shape morphological and phytochemical responses in kratom.Frontiers in plant science · 2026Article
- Review
- Plant stress and proteomics in medicinal plants.Frontiers in plant science · 2025Review
- Exploring Bioactive Compounds of Rauvolfia tetraphylla L. (RT) for 3CLprotease of SARS-CoV2: GC-MS Analysis and In-Silico Studies.Cell biochemistry and biophysics · 2024Article
- A Transcriptomic and Metabolomic Study on the Biosynthesis of Iridoids inPlants (Basel, Switzerland) · 2024Article
- Environmental factors influencing potential distribution ofFrontiers in plant science · 2023Article
- Molecular cloning and functional characterization of BcTSA in the biosynthesis of indole alkaloids inFrontiers in plant science · 2023Article
- Genome-wide identification and characterization of active ingredients related β-Glucosidases in Dendrobium catenatum.BMC genomics · 2022Article
- Molecular and Physiological Responses ofInternational journal of molecular sciences · 2022Article
- Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels inMarine drugs · 2022Article
- Morphophysiological and Proteomic Responses on Plants of Irradiation with Electromagnetic Waves.International journal of molecular sciences · 2021Review
- Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering.Biotechnology letters · 2021Review
- Boosting of Antioxidants and Alkaloids inPlants (Basel, Switzerland) · 2021Article
- UV-B light and its application potential to reduce disease and pest incidence in crops.Horticulture research · 2021Review
- Novel Transcriptome Study and Detection of Metabolic Variations in UV-B-Treated Date Palm (International journal of molecular sciences · 2021Article
- Effects of Light on Secondary Metabolite Biosynthesis in Medicinal Plants.Frontiers in plant science · 2021Review
- Article
- Transcriptomic Landscape of MedicinalFrontiers in plant science · 2020Review
- Analysis of chickpea gene co-expression networks and pathways during heavy metal stress.Journal of biosciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. In the present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis in C. roseus using proteomic technique. The contents of the detectable alkaloids ajmalicine, vindoline, catharanthine, and strictosidine in C. roseus were significantly increased under binary stress. Proteomic analysis revealed that the abundance of proteins related to tricarboxylic acid cycle and cell wall was largely increased; while, that of proteins related to tetrapyrrole synthesis and photosynthesis was decreased. Of note, 10-hydroxygeraniol oxidoreductase, which is involved in the biosynthesis of indole alkaloid was two-fold more abundant in treated group compared to the control. In addition, mRNA expression levels of genes involved in the indole alkaloid biosynthetic pathway indicated an up-regulation in their transcription in C. roseus under UV-B irradiation. These results suggest that binary stress might negatively affect the process of photosynthesis in C. roseus. In addition, the induction of alkaloid biosynthesis appears to be responsive to binary stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.