ArticleFrontiers in plant science2015
Candidate effector proteins of the necrotrophic apple canker pathogen Valsa mali can suppress BAX-induced PCD.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 77 citations in OpenAlex.
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- Explorations of a novel effector CcAA9-20333 from Colletotrichum coccodes: the potential roles played in host immunity.Plant cell reports · 2025Article
- The Valsa mali Effector VmSR1 Accelerates the Degradation of Tudor-SN2 to Suppress RNA Silencing and Plant Immunity.Molecular plant pathology · 2025Article
- Genome-wide characterization of effector proteins in Fusarium zanthoxyli and their effects on plant's innate immunity responses.BMC plant biology · 2025Article
- Effector-Mediated Suppression of Programmed Cell Death byJournal of fungi (Basel, Switzerland) · 2024Article
- Effector CLas0185 targets methionine sulphoxide reductase B1 of Citrus sinensis to promote multiplication of 'Candidatus Liberibacter asiaticus' via enhancing enzymatic activity of ascorbate peroxidase 1.Molecular plant pathology · 2024Article
- Multi-Omics Approaches Provide New Insights into the Identification of Putative Fungal Effectors fromMicroorganisms · 2024Article
- Identification of Mycoviruses in the Pathogens of Fragrant Pear Valsa Canker from Xinjiang in China.Viruses · 2024Article
- TheAutophagy · 2023Article
- A prophage-encoded effector from "Candidatus Liberibacter asiaticus" targets ASCORBATE PEROXIDASE6 in citrus to facilitate bacterial infection.Molecular plant pathology · 2023Article
- Comparative genomics of five Valsa species gives insights on their pathogenicity evolution.G3 (Bethesda, Md.) · 2023Article
- Valsa mali secretes an effector protein VmEP1 to target a K homology domain-containing protein for virulence in apple.Molecular plant pathology · 2022Article
- AInternational journal of molecular sciences · 2022Article
- A Putative Effector LtCSEP1 fromPlants (Basel, Switzerland) · 2022Article
- A novel effector, CsSp1, from Bipolaris sorokiniana, is essential for colonization in wheat and is also involved in triggering host immunity.Molecular plant pathology · 2022Article
- Mechanisms ofJournal of fungi (Basel, Switzerland) · 2022Article
- Two NIS1-like proteins from apple canker pathogen (Valsa mali) play distinct roles in plant recognition and pathogen virulence.Stress biology · 2022Article
- The Transcription FactorFrontiers in microbiology · 2022Article
- Unrelated Fungal Rust Candidate Effectors Act on Overlapping Plant Functions.Microorganisms · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canker caused by the Ascomycete Valsa mali is the most destructive disease of apple in Eastern Asia, resulting in yield losses of up to 100%. This necrotrophic fungus induces severe necrosis on apple, eventually leading to the death of the whole tree. Identification of necrosis inducing factors may help to unravel the molecular bases for colonization of apple trees by V. mali. As a first step toward this goal, we identified and characterized the V. mali repertoire of candidate effector proteins (CEPs). In total, 193 secreted proteins with no known function were predicted from genomic data, of which 101 were V. mali-specific. Compared to non-CEPs predicted for the V. mali secretome, CEPs have shorter sequence length and a higher content of cysteine residues. Based on transient over-expression in Nicotiana benthamiana performed for 70 randomly selected CEPs, seven V. mali Effector Proteins (VmEPs) were shown to significantly suppress BAX-induced PCD. Furthermore, targeted deletion of VmEP1 resulted in a significant reduction of virulence. These results suggest that V. mali expresses secreted proteins that can suppress PCD usually associated with effector-triggered immunity (ETI). ETI in turn may play an important role in the V. mali-apple interaction. The ability of V. mali to suppress plant ETI sheds a new light onto the interaction of a necrotrophic fungus with its host plant.
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