ArticleFrontiers in plant science2015
P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Proline Dehydrogenase GeneJournal of fungi (Basel, Switzerland) · 2026Article
- Proline: A Reliable Biochemical Marker of Plant Abiotic Stress Tolerance?Plants (Basel, Switzerland) · 2026Review
- Physiological and transcriptomic analyses of Rosa persica in response to drought stress and functional validation of the transcription factor RpERF113-like.BMC genomics · 2026Article
- Article
- Effects of proline on growth performance, protein synthesis and cold resistance in white shrimp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- The Proline Dehydrogenase GeneInternational journal of molecular sciences · 2025Article
- Nanomedicines Targeting Metabolic Pathways in the Tumor Microenvironment: Future Perspectives and the Role of AI.Metabolites · 2025Review
- Ornithine enhances common bean growth and defense against white mold disease via interfering withFrontiers in plant science · 2025Article
- Physiological and metabolic analyses reveal the proline-mediated flowering delay mechanism inFrontiers in plant science · 2024Article
- Dissecting the biochemical and molecular-genetic regulation of diverse metabolic pathways governing aroma formation in indigenous aromatic indica rice varieties.Molecular biology reports · 2023Article
- Hypovirus infection induces proliferation and perturbs functions of mitochondria in the chestnut blight fungus.Frontiers in microbiology · 2023Article
- HAntioxidants (Basel, Switzerland) · 2022Article
- The role of the electron-transfer flavoprotein: ubiquinone oxidoreductase following carbohydrate starvation in Arabidopsis cell cultures.Plant cell reports · 2022Article
- Expression of Arabidopsis Ornithine Aminotransferase (AtOAT) encoded gene enhances multiple abiotic stress tolerances in wheat.Plant cell reports · 2021Article
- Incomplete proline catabolism drives premature sperm aging.Aging cell · 2021Article
- Mapping proteome-wide targets of protein kinases in plant stress responses.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Role of Proline in Pathogen and Host Interactions.Antioxidants & redox signaling · 2019Review
- Biological Roles of Ornithine Aminotransferase (OAT) in Plant Stress Tolerance: Present Progress and Future Perspectives.International journal of molecular sciences · 2018Review
- Selection and regeneration of Vitis vinifera Chardonnay hydroxyproline-resistant calli.Protoplasma · 2018Article
- Differential control and function of Arabidopsis ProDH1 and ProDH2 genes on infection with biotrophic and necrotrophic pathogens.Molecular plant pathology · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants facing adverse conditions usually alter proline (Pro) metabolism, generating changes that help restore the cellular homeostasis. These organisms synthesize Pro from glutamate (Glu) or ornithine (Orn) by two-step reactions that share Δ(1) pyrroline-5-carboxylate (P5C) as intermediate. In the catabolic process, Pro is converted back to Glu using a different pathway that involves Pro dehydrogenase (ProDH), P5C dehydrogenase (P5CDH), and P5C as intermediate. Little is known about the coordination of the catabolic and biosynthetic routes under stress. To address this issue, we analyzed how P5CDH affects the activation of Pro synthesis, in Arabidopsis tissues that increase ProDH activity by transient exposure to exogenous Pro, or infection with Pseudomonas syringae pv. tomato. Wild-type (Col-0) and p5cdh mutant plants subjected to these treatments were used to monitor the Pro, Glu, and Orn levels, as well as the expression of genes from Pro metabolism. Col-0 and p5cdh tissues consecutively activated ProDH and Pro biosynthetic genes under both conditions. However, they manifested a different coordination between these routes. When external Pro supply was interrupted, wild-type leaves degraded Pro to basal levels at which point Pro synthesis, mainly via Glu, became activated. Under the same condition, p5cdh leaves sustained ProDH induction without reducing the Pro content but rather increasing it, apparently by stimulating the Orn pathway. In response to pathogen infection, both genotypes showed similar trends. While Col-0 plants seemed to induce both Pro biosynthetic routes, p5cdh mutant plants may primarily activate the Orn route. Our study contributes to the functional characterization of P5CDH in biotic and abiotic stress conditions, by revealing its capacity to modulate the fate of P5C, and prevalence of Orn or Glu as Pro precursors in tissues that initially consumed Pro.
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