ReviewFrontiers in microbiology2015
Chromosome replication, cell growth, division and shape: a personal perspective.
Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Multiparametric quantification of bacterial cells using digital holographic microscopy.Scientific reports · 2025Article
- Molecular Cytology of 'Little Animals': Personal Recollections ofLife (Basel, Switzerland) · 2023Review
- The Bacterial Nucleoid: From Electron Microscopy to Polymer Physics-A Personal Recollection.Life (Basel, Switzerland) · 2023Review
- Transient enhanced cell division by blocking DNA synthesis inMicrobiology (Reading, England) · 2020Article
- Too Much of a Good Thing: How Ectopic DNA Replication Affects Bacterial Replication Dynamics.Frontiers in microbiology · 2020Review
- Methods for quantification of growth and productivity in anaerobic microbiology and biotechnology.Folia microbiologica · 2019Review
- Does the Nucleoid Determine Cell Dimensions inFrontiers in microbiology · 2019Article
- Fundamental principles in bacterial physiology-history, recent progress, and the future with focus on cell size control: a review.Reports on progress in physics. Physical Society (Great Britain) · 2018Review
- Using stochastic cell division and death to probe minimal units of cellular replication.New journal of physics · 2018Article
- Different Amounts of DNA in Newborn Cells ofFrontiers in microbiology · 2018Article
- Does the eclipse limit bacterial nucleoid complexity and cell width?Synthetic and systems biotechnology · 2017Review
- Sizing up the bacterial cell cycle.Nature reviews. Microbiology · 2017Review
- Chromosome segregation drives division site selection inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Evidence of Multi-Domain Morphological Structures in Living Escherichia coli.Scientific reports · 2017Article
- Analysis of Noise Mechanisms in Cell-Size Control.Biophysical journal · 2017Article
- In Vivo study of naturally deformed Escherichia coli bacteria.Journal of bioenergetics and biomembranes · 2016Article
- Adder and a coarse-grained approach to cell size homeostasis in bacteria.Current opinion in cell biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origins of Molecular Biology and Bacterial Physiology are reviewed, from our personal standpoints, emphasizing the coupling between bacterial growth, chromosome replication and cell division, dimensions and shape. Current knowledge is discussed with historical perspective, summarizing past and present achievements and enlightening ideas for future studies. An interactive simulation program of the bacterial cell division cycle (BCD), described as "The Central Dogma in Bacteriology," is briefly represented. The coupled process of transcription/translation of genes encoding membrane proteins and insertion into the membrane (so-called transertion) is invoked as the functional relationship between the only two unique macromolecules in the cell, DNA and peptidoglycan embodying the nucleoid and the sacculus respectively. We envision that the total amount of DNA associated with the replication terminus, so called "nucleoid complexity," is directly related to cell size and shape through the transertion process. Accordingly, the primary signal for cell division transmitted by DNA dynamics (replication, transcription and segregation) to the peptidoglycan biosynthetic machinery is of a physico-chemical nature, e.g., stress in the plasma membrane, relieving nucleoid occlusion in the cell's center hence enabling the divisome to assemble and function between segregated daughter nucleoids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.