ArticleFrontiers in behavioral neuroscience2015
GABAergic feedback signaling into the calyces of the mushroom bodies enables olfactory reversal learning in honey bees.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- When a bigger brain is better: The case of bee olfactory learning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Comprehension of the age-dependent gut and brain interaction of honey bee workers by integration of multi omics approaches.Journal of advanced research · 2026Article
- Visual learning performance in free-flying honey bees is independent of sucrose and light responsiveness and depends on training context.Scientific reports · 2026Article
- Form informs function: innervation patterns of projection neurons correspond to response profiles of mushroom body output neurons during olfactory-visual integration.Frontiers in physiology · 2026Article
- Learning performance and GABAergic pathway link to deformed wing virus in the mushroom bodies of naturally infected honey bees.The Journal of experimental biology · 2024Article
- Article
- Cognitive limits of larvalLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Investigating visual navigation using spiking neural network models of the insect mushroom bodies.Frontiers in physiology · 2024Article
- Individual consistency in the learning abilities of honey bees: cognitive specialization within sensory and reinforcement modalities.Animal cognition · 2023Article
- Differential Brain Expression Patterns of microRNAs Related to Olfactory Performance in Honey Bees (Genes · 2023Article
- The Neural Signature of Visual Learning Under Restrictive Virtual-Reality Conditions.Frontiers in behavioral neuroscience · 2022Article
- Fruit flies can learn non-elemental olfactory discriminations.Proceedings. Biological sciences · 2020Article
- Honeybees solve a multi-comparison ranking task by probability matching.Proceedings. Biological sciences · 2020Article
- Reversal learning inLearning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Quantifying the impact of pesticides on learning and memory in bees.The Journal of applied ecology · 2018Article
- Abstract concept learning in a simple neural network inspired by the insect brain.PLoS computational biology · 2018Article
- Relationship between brain plasticity, learning and foraging performance in honey bees.PloS one · 2018Article
- Associative Learning of Stimuli Paired and Unpaired With Reinforcement: Evaluating Evidence From Maggots, Flies, Bees, and Rats.Frontiers in psychology · 2018Article
- Neural Organization of A3 Mushroom Body Extrinsic Neurons in the Honeybee Brain.Frontiers in neuroanatomy · 2018Article
- Experience during early adulthood shapes the learning capacities and the number of synaptic boutons in the mushroom bodies of honey bees (Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
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4 authors.
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Abstract
In reversal learning, subjects first learn to respond to a reinforced stimulus A and not to a non-reinforced stimulus B (A(+) vs. B(-)) and then have to learn the opposite when stimulus contingencies are reversed (A(-) vs. B(+)). This change in stimulus valence generates a transitory ambiguity at the level of stimulus outcome that needs to be overcome to solve the second discrimination. Honey bees (Apis mellifera) efficiently master reversal learning in the olfactory domain. The mushroom bodies (MBs), higher-order structures of the insect brain, are required to solve this task. Here we aimed at uncovering the neural circuits facilitating reversal learning in honey bees. We trained bees using the olfactory conditioning of the proboscis extension reflex (PER) coupled with localized pharmacological inhibition of Gamma-AminoButyric Acid (GABA)ergic signaling in the MBs. We show that inhibition of ionotropic but not metabotropic GABAergic signaling into the MB calyces impairs reversal learning, but leaves intact the capacity to perform two consecutive elemental olfactory discriminations with ambiguity of stimulus valence. On the contrary, inhibition of ionotropic GABAergic signaling into the MB lobes had no effect on reversal learning. Our results are thus consistent with a specific requirement of the feedback neurons (FNs) providing ionotropic GABAergic signaling from the MB lobes to the calyces for counteracting ambiguity of stimulus valence in reversal learning.
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