ReviewFrontiers in behavioral neuroscience2015
Pain perception in people with Down syndrome: a synthesis of clinical and experimental research.
Review in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Investigating pain-related medication use and contribution to polypharmacy in adults with intellectual disabilities: a systematic review.BMC medicine · 2024Pooled it
- Increased heart rate functions as a signal of acute distress in non-communicating persons with intellectual disability.Scientific reports · 2021Trial
- Review
- Acute postoperative complications after spine deformity correction in patients with Down syndrome.Journal of children's orthopaedics · 2024Article
- PROs for RARE: protocol for development of a core patient reported outcome set for individuals with genetic intellectual disability.Orphanet journal of rare diseases · 2024Article
- Pain Management in the Most Vulnerable Intellectual Disability: A Review.Pain and therapy · 2023Review
- Heart rate monitoring to detect acute pain in non-verbal patients: a study protocol for a randomized controlled clinical trial.BMC psychiatry · 2023Article
- Medical vulnerability of individuals with Down syndrome to severe COVID-19-data from the Trisomy 21 Research Society and the UK ISARIC4C survey.EClinicalMedicine · 2021Article
- Structural magnetic resonance imaging demonstrates volumetric brain abnormalities in down syndrome: Newborns to young adults.NeuroImage. Clinical · 2021Article
- Reproducibility of foot dimensions measured from 3-dimensional foot scans in children and adolescents with Down syndrome.Journal of foot and ankle research · 2020Article
- Structural magnetic resonance imaging demonstrates abnormal cortical thickness in Down syndrome: Newborns to young adults.NeuroImage. Clinical · 2019Article
- Article
- Prescription of potentially inappropriate medications among older people with intellectual disability: a register study.BMC pharmacology & toxicology · 2017Article
- Supportive care utilization and treatment toxicity in children with Down syndrome and acute lymphoid leukaemia at free-standing paediatric hospitals in the United States.British journal of haematology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
People with an intellectual disability experience both acute and chronic pain with at least the same frequency as the general population. However, considerably less is known about the pain perception of people with Down syndrome. In this review paper, we evaluated the available clinical and experimental evidence. Some experimental studies of acute pain have indicated that pain threshold was higher than normal but only when using a reaction time method to measure pain sensitivity. However, when reaction time is not part of the calculation of the pain threshold, pain sensitivity in people with Down syndrome is in fact lower than normal (more sensitive to pain). Clinical studies of chronic pain have shown that people with an intellectual disability experience chronic pain and within that population, people with Down syndrome also experience chronic pain, but the precise prevalence of chronic pain in Down syndrome has yet to be established. Taken together, the literature suggests that people with Down syndrome experience pain, both acute and chronic, with at least the same frequency as the rest of the population. Furthermore, the evidence suggests that although acute pain expression appears to be delayed, once pain is registered, there appears to be a magnified pain response. We conclude by proposing an agenda for future research in this area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.