Evidence map›Paper›PMID 26283900›Full record

ReviewFrontiers in neuroscience2015

Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes.

Luca Steardo, Maria R Bronzuoli, Aniello Iacomino, Giuseppe Esposito, Luca Steardo, Caterina Scuderi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Astrocyte biomarkers GFAP and YKL-40 mediate early Alzheimer's disease progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  5. Article
  6. Article
  7. The Role of PPAR Alpha in the Modulation of Innate Immunity.International journal of molecular sciences · 2021
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luca SteardoDepartment of Psychiatry, University of Naples SUN Naples, Italy.
Maria R BronzuoliDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome Rome, Italy.
Aniello IacominoFaculty of Psychology, University of Rome "G. Marconi" Rome, Italy.
Giuseppe EspositoDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome Rome, Italy.
Luca SteardoDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome Rome, Italy.
Caterina ScuderiDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data from animal models and Alzheimer's disease (AD) subjects provide clear evidence for an activation of inflammatory pathways during the pathogenetic course of such illness. Biochemical and neuropathological studies highlighted an important cause/effect relationship between inflammation and AD progression, revealing a wide range of genetic, cellular, and molecular changes associated with the pathology. In this context, glial cells have been proved to exert a crucial role. These cells, in fact, undergo important morphological and functional changes and are now considered to be involved in the onset and progression of AD. In particular, astrocytes respond quickly to pathology with changes that have been increasingly recognized as a continuum, with potentially beneficial and/or negative consequences. Although it is now clear that activated astrocytes trigger the neuroinflammatory process, however, the precise mechanisms have not been completely elucidated. Neuroinflammation is certainly a multi-faceted and complex phenomenon and, especially in the early stages, exerts a reparative intent. However, for reasons not yet all well known, this process goes beyond the physiologic control and contributes to the exacerbation of the damage. Here we scrutinize some evidence supporting the role of astrocytes in the neuroinflammatory process and the possibility that these cells could be considered a promising target for future AD therapies.

Indexed as

Alzheimer's diseaseastrocyteglianeurodegenerationneuroinflammation

Identifiers

PMID26283900
PMCPMC4518161

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.