ArticleJournal of natural science, biology, and medicine
Anti-thyroid peroxidase antibody positivity during early pregnancy is associated with pregnancy complications and maternal morbidity in later life.
Article in Journal of natural science, biology, and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Autoimmune Processes and Chronic Inflammation as Independent Risk Factors for Metabolic Complications in Women with Polycystic Ovary Syndrome.Metabolites · 2025Article
- A study of autoimmune thyroid disease in pregnant women and its effect on fetal and maternal outcome.Journal of family medicine and primary care · 2024Article
- Update on therapeutic use of levothyroxine for the management of hypothyroidism during pregnancy.Endocrine connections · 2024Review
- Vitamin D levels in non-pregnant women with a history of recurrent pregnancy loss with and without autoantibodies.Caspian journal of internal medicine · 2024Article
- The association of Treg and Th17 cells development factors and anti-TPO autoantibodies in patients with recurrent pregnancy loss.BMC research notes · 2023Article
- Article
- The effects of metabolic indicators and immune biomarkers on pregnancy outcomes in women with recurrent spontaneous abortion: a retrospective study.Frontiers in endocrinology · 2023Article
- A novel update on vitamin D in recurrent pregnancy loss (Review).Molecular medicine reports · 2021Review
- The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy.Disease markers · 2020Review
- Association of Hypothyroidism and Anti-Thyroid Antibodies With Preterm Delivery: A Cross Sectional Study.Journal of family & reproductive health · 2017Article
- Knowledge of Thyroid Disorders during Pregnancy among General Practitioners in Iran.International journal of endocrinology and metabolism · 2017Article
- The Effect of Anti-Thyroid Peroxidase Antibodies on Pregnancy Outcomes in Euthyroid Women.Journal of clinical and diagnostic research : JCDR · 2016Article
- Prevalence of Thyroid Peroxidase Antibody and Pregnancy Outcome in Euthyroid Autoimmune Positive Pregnant Women from a Tertiary Care Center in Haryana.Indian journal of endocrinology and metabolismArticle
- Interleukin Activity in Miscarried Women with Toxoplasmosis and Anti Thyroid Peroxidase (Anti-TPO).Iranian journal of parasitologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe assessed the impact of detecting anti-thyroid peroxidase antibodies (anti-TPO-Ab) in the first trimester of pregnancy on pregnancy outcomes and maternal thyroid function during the postpartum period. MATERIALS AND
methodsIn a prospective study consisting 400 pregnant women (8-12 weeks pregnant) were screened for their thyroid profile and followed-up to 12 weeks postpartum. Patients with abnormal thyroid function at 12 weeks postpartum were further followed-up with repeated assessment of thyroid stimulating hormone (TSH) and serum-free thyroxine-4 levels at 8 weeks interval up to 12 months postpartum.
results11.5% of the subjects were positive for anti-TPO-Ab who had mean TSH level of 2.31 μIU/ml, which was significantly (P- 0.0001) higher than pregnant women negative for anti-TPO-Ab (1.73 μIU/ml). Increased incidence of miscarriage was observed in anti-TPO positive mothers when compared to antibody negative mothers. Postpartum thyroid dysfunction developed in 4.7% cases at 12 weeks, among them antibody positivity was observed in 81.25% of subjects. In 18.75% mothers positive for anti-TPO-Ab, the thyroid dysfunction persisted up to 12 months postpartum.
conclusionsThyroid antibodies detected in early pregnancy seems to be predicting pregnancy complications and later maternal thyroid disease related morbidity.
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