ReviewThe American journal of tropical medicine and hygiene2015
Patterns of Hepatosplenic Brucella Abscesses on Cross-Sectional Imaging: A Review of Clinical and Imaging Features.
Review in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- A case of hepatic-splenic abscess in a non-endemic area of brucellosis: insights from complex infection with brucellosis.BMC infectious diseases · 2025Article
- The snowflake sign.Abdominal radiology (New York) · 2025Review
- Brucellosis: Unveiling the complexities of a pervasive zoonotic disease and its global impacts.Open veterinary journal · 2024Review
- Case Report: Role of Point-of-Care Ultrasound in the Diagnosis of Bacillary Angiomatosis.The American journal of tropical medicine and hygiene · 2023Article
- "Sponge pattern" of the spleen: a rarely described high-frequency ultrasound pattern in HIV-positive patients.The ultrasound journal · 2023Article
- Typical imaging finding of hepatic infections: a pictorial essay.Abdominal radiology (New York) · 2021Review
- Hepatic Stellate Cells and Hepatocytes as Liver Antigen-Presenting Cells duringPathogens (Basel, Switzerland) · 2020Article
- Hepatosplenic brucella abscesses on computed tomography and magnetic resonance imaging: Case series.Medicine · 2019Article
- Hepatic Brucelloma Diagnosis and Long-Term Treatment, France.Emerging infectious diseases · 2019Article
- Brucellosis accompanied by haemophagocytic lymphohistiocytosis and multiple splenic abscesses in a patient with depression.BMJ case reports · 2018Article
- Acute liver failure complication of brucellosis infection: a case report and review of the literature.Journal of medical case reports · 2018Review
- Point-of-Care Ultrasound for Extrapulmonary Tuberculosis in India: A Prospective Cohort Study in HIV-Positive and HIV-Negative Presumptive Tuberculosis Patients.The American journal of tropical medicine and hygiene · 2018Article
- Point-of-Care Ultrasound Assessment of Tropical Infectious Diseases--A Review of Applications and Perspectives.The American journal of tropical medicine and hygiene · 2016Review
- Application of Ultrasonography in the Diagnosis of Infectious Diseases in Resource-Limited Settings.Current infectious disease reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While diffuse involvement of liver and spleen is frequently seen in brucellosis, suppurative abscesses caused by Brucella are less common but well described. With the increased availability of cross-sectional imaging techniques, reports have become more frequent. Four patients with hepatosplenic abscesses caused by Brucella spp. are described and included in a review of 115 previously published cases. Clinical characteristics and patterns on ultrasound (US) and computed tomography imaging were analyzed. Furthermore, the proportion of patients with brucellosis affected by suppurative hepatosplenic lesions was estimated. Hepatosplenic abscesses were seen in 1.2% of patients with brucellosis and were mostly caused by Brucella melitensis. Imaging analysis revealed two main distinct patterns. Solitary abscesses involving liver more frequently than spleen, and showing characteristic central calcifications, characterize the first pattern. Multiple smaller abscesses, frequent spleen involvement, and absence of calcifications characterize the second pattern. Blood and aspirate cultures were frequently negative, however, the positivity rate increased over the past years. Indirect Coombs test was positive in 96%. Half of the patients were cured by antibiotic treatment; case fatality in this series was 1.9%. Hepatosplenic abscesses due to Brucella infections have characteristic imaging findings. Clinicians should be aware of these and the proactive use of cross-sectional imaging, particularly US, should be encouraged in endemic regions.
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