ArticleThe American journal of tropical medicine and hygiene2015
Use of Rapid Influenza Testing to Reduce Antibiotic Prescriptions Among Outpatients with Influenza-Like Illness in Southern Sri Lanka.
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Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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28citing papers in PubMed, 2 pooled it
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections: systematic review and meta-analysis.BMC infectious diseases · 2022Pooled it
- Systematic review of the impact of point-of-care testing for influenza on the outcomes of patients with acute respiratory tract infection.Reviews in medical virology · 2018Pooled it
- Impact of Real-Time, On-Demand Influenza and Respiratory Syncytial Virus Testing at Point-of-Care on Antibiotic Prescribing and Clinical Outcome in Pediatric Outpatients With Acute Respiratory Illness: A Prospective, Quasi-Randomized, Controlled Study.Influenza and other respiratory viruses · 2026Trial
- Article
- Impact of multiplex PCR respiratory viral panel testing on antibiotic utilisation in children with acute febrile and respiratory illnesses.BMJ paediatrics open · 2025Article
- Academic global health collaboration: the Ruhuna-Duke partnership.Global health action · 2025Article
- Point of Care Nucleic Acid Testing for Influenza-Like Illness: A Cost-Consequence Analysis for High-Risk Patients in Primary Care in Germany.Advances in therapy · 2025Article
- Article
- Cost-of-illness comparison between clinical judgment and molecular point-of-care testing for influenza-like illness patients in Germany.NPJ primary care respiratory medicine · 2023Article
- Clinical Features of COVID-19, Dengue, and Influenza among Adults Presenting to Emergency Departments and Urgent Care Clinics-Puerto Rico, 2012-2021.The American journal of tropical medicine and hygiene · 2023Article
- Rapid Diagnostic Tests to Guide Case Management of and Improve Antibiotic Stewardship for Pediatric Acute Respiratory Illnesses in Resource-Constrained Settings: a Prospective Cohort Study in Southwestern Uganda.Microbiology spectrum · 2021Observational
- Strategies Used for Implementing and Promoting Adherence to Antibiotic Guidelines in Low- and Lower-Middle-Income Countries: A Systematic Review.Tropical medicine and infectious disease · 2021Review
- Pediatricians' Compliance to the Clinical Management Guidelines for Community-Acquired Pneumonia in Infants and Young Children in Pakistan.Healthcare (Basel, Switzerland) · 2021Article
- Colonization with multidrug-resistant Enterobacteriaceae among infants: an observational study in southern Sri Lanka.Antimicrobial resistance and infection control · 2021Observational
- Differences in antibiotic and antiviral use in people with confirmed influenza: a retrospective comparison of rapid influenza PCR and multiplex respiratory virus PCR tests.BMC infectious diseases · 2021Article
- Antibiotics and antimicrobial resistance in the COVID-19 era: Perspective from resource-limited settings.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- Point-prevalence survey of outpatient antibiotic prescription at a tertiary medical center in Sri Lanka: opportunities to improve prescribing practices for respiratory illnesses.BMC infectious diseases · 2021Article
- Reducing Antibiotic Use in Ambulatory Care Through Influenza Vaccination.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Viral Etiology, Clinical Features and Antibiotic Use in Children <5 Years of Age in the Gambia Presenting With Influenza-like Illness.The Pediatric infectious disease journal · 2020Article
- Antimicrobial resistance in the Pacific Island countries and territories.BMJ global health · 2020Review
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Authors and funding
11 authors at 1 institution in 2 countries.
L Gayani TillekeratneDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina gayani.tillekeratne@dm.duke.edu.
Champica K BodinayakeDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina.
Ajith NagahawatteDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina.
Dhammika VidanagamaDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina.
Vasantha DevasiriDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina.
Wasantha Kodikara ArachchiDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina.
Ruvini KurukulasooriyaDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina.
Aruna Dharshan De SilvaDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina.
Truls ØstbyeDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina.
Megan E RellerDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina.
Christopher W WoodsDuke Global Health Institute, Durham, North Carolina; Department of Medicine, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Department of Microbiology, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Teaching Hospital Karapitiya, Galle, Sri Lanka; Department of Pediatrics, Faculty of Medicine, Ruhuna University, Galle, Sri Lanka; Duke-Ruhuna Collaborative Research Center, Ruhuna University, Galle, Sri Lanka; Genetech Research Institute, Colombo, Sri Lanka; Department of Community and Family Medicine, Duke University, Durham, North Carolina; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Medicine, Duke University, Durham, North Carolina.
University of Ruhuna · LK
Funding
Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)R25TW009337 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEIMBURGER, DOUGLAS CORBETT, VERMUND, STEN H. · 2012 to 2016
$6.3MFIC NIH HHS R25 TW009337
Abstract
Acute respiratory tract infections (ARTIs) are a common reason for unnecessary antibiotic prescriptions worldwide. Our objective was to determine if providing access to rapid influenza test results could reduce antibiotic prescriptions for ARTIs in a resource-limited setting. We conducted a prospective, pre-post study from March 2013 to October 2014. Outpatients presenting to a hospital in Sri Lanka were surveyed for influenza-like illness-onset of fever ≥ 38.0°C and cough in prior 7 days. Enrolled patients were administered a structured questionnaire, physical examination, and nasal/nasopharyngeal sampling for rapid influenza A/B testing. Influenza test results were released only during phase 2 (January-October 2014). We enrolled 571 patients with ILI-316 in phase 1 and 241 in phase 2. The proportion positive for influenza was 46.5% in phase 1 and 28.6% in phase 2, P < 0.001. Between phases, antibiotic prescriptions decreased from 81.3% to 69.3% (P = 0.001) among all patients and from 83.7% to 62.3% (P = 0.001) among influenza-positive patients. On multivariable analysis, a positive influenza result during phase 2 was associated with lower odds of antibiotic prescriptions (OR = 0.50, 95% CI = 0.26-0.95). This prospective study suggests that providing access to rapid influenza testing may reduce unnecessary antibiotic prescriptions in resource-limited settings.
Indexed as
AdolescentAdultAnti-Bacterial AgentsChildChild, PreschoolCohort StudiesCoughFemaleFeverHumansInappropriate PrescribingInfluenza, HumanMaleOutpatientsPractice Patterns, Physicians'Prospective StudiesAnti-Bacterial Agents
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.