Evidence map›Paper›PMID 26283743›Full record

Trial reportThe American journal of tropical medicine and hygiene2015

Clinical Efficacy of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria at the China-Myanmar Border.

Ying Wang, Zhaoqing Yang, Lili Yuan, Guofa Zhou, Daniel Parker, Ming-Chieh Lee, Guiyun Yan, Qi Fan, Yuping Xiao, Yaming Cao and 1 more

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Antimicrobial agents and chemotherapy · 2023
    Article
  4. Article
  5. Different In Vitro Drug Susceptibility Profile ofTropical medicine and infectious disease · 2022
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  6. Article
  7. Article
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  11. Molecular Surveillance and in vitro Drug Sensitivity Study ofThe American journal of tropical medicine and hygiene · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Role of K13 Mutations in Artemisinin-Based Combination Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ying WangInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
Zhaoqing YangInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
Lili YuanInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
Guofa ZhouInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
Daniel ParkerInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
Ming-Chieh LeeInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
Guiyun YanInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
Qi FanInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
Yuping XiaoInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
Yaming CaoInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania.
Liwang CuiInstitute of Tropical Medicine, Third Military Medical University, Chongqing, China; Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Program in Public Health, University of California at Irvine, Irvine, California; Dalian Institute of Biotechnology, Dalian, Liaoning, China; Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China; Department of Entomology, Pennsylvania State University, University Park, Pennsylvania luc2@psu.edu.
University of California, Irvine · US

Funding

Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
NIAID NIH HHS U19 AI089672NIAID NIH HHS U19AI089672
6 · The paper itself

Abstract

Artemisinin-based combination therapies (ACTs) are currently used as the first-line therapy for uncomplicated Plasmodium falciparum malaria. However, the recent emergence and/or spread of artemisinin resistance in parts of Greater Mekong Subregion (GMS) of southeast Asia requires close monitoring of the therapeutic efficacy of ACTs. This study was conducted from March 2012 to December 2013 in four clinics and seven villages along the China-Myanmar border. A total of 109 patients with uncomplicated falciparum malaria were treated with dihydroartemisinin-piperaquine (DP) and followed up on days 1, 2, 3, 7, 14, 21, 28, and 42 after treatment. A total of 71 patients (22 children and 49 adults) completed the 42-day follow-up. DP remained highly efficacious for treatment of uncomplicated falciparum malaria with an overall 42-day cure rate of 100%. The day 3 parasite-positive rate was 7.04% (5/71). Within 14 days of treatment, a total of 13 (18.31%) patients had detectable gametocytes and a large proportion of these were persistent from the first three days of treatment. The presence of gametocytes in patients through 14 days after DP treatment suggests that the incorporation of a single dose of primaquine for clearing gametocytemia should be considered for blocking parasite transmission.

Indexed as

AdolescentAdultAntimalarialsArtemisininsChildChild, PreschoolChinaDrug Therapy, CombinationFemaleHumansInfantMalaria, FalciparumMaleMiddle AgedMyanmarPiperazinesAntimalarialsArtemisininsartenimolpiperaquinePiperazinesQuinolines

Identifiers

PMID26283743
PMCPMC4720921
OpenAlexW2119652588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.