Evidence map›Paper›PMID 26283579›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2015

Rapid 3D Extrusion of Synthetic Tumor Microenvironments.

Joshua M Grolman, Douglas Zhang, Andrew M Smith, Jeffrey S Moore, Kristopher A Kilian

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Review
  2. Article
  3. 3D bioprinting innovations: a new frontier in breast cancer research.Medical oncology (Northwood, London, England) · 2025
    Review
  4. 3D Hybrid Bioprinting for Complex Multi-Tissue Engineering.bioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. A Cell Pre-Wrapping Seeding Technique for Hydrogel-Based Tubular Organ-On-A-Chip.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  12. Review
  13. Review
  14. Engineering Heterogeneous Tumor Models for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  15. Review
  16. Review
  17. Application and Progress of Cultured Models of Gallbladder Carcinoma.Journal of clinical and translational hepatology · 2023
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joshua M GrolmanDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Douglas ZhangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Andrew M SmithDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Jeffrey S MooreDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Kristopher A KilianDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Funding

Next-Generation Quantum Dots for Molecular and Cellular Imaging of CancerR00CA153914 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SMITH, ANDREW MICHAEL · 2012 to 2014
$709k
Deconstructing the cues in the mesenchymal stem cell microenvironment that promotR21HL121757 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KILIAN, KRISTOPHER ALAN · 2014 to 2015
$398k
NCI NIH HHS R00 CA153914NCI NIH HHS R00CA153914NHLBI NIH HHS R21 HL121757
6 · The paper itself

Abstract

The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

Indexed as

Tissue ScaffoldsAdenocarcinomaAlginatesAnimalsBiomimetic MaterialsBreast NeoplasmsCell Line, TumorCell MovementCell SurvivalCoculture TechniquesEquipment DesignGlucuronic AcidHexuronic AcidsHumansHydrogelsLab-On-A-Chip DevicesAlginatesGlucuronic AcidHexuronic AcidsHydrogelsmicrofluidicspatterned hydrogelstissue engineeringtumor microenvironments

Identifiers

PMID26283579
PMCPMC4745120

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.