ArticleEuropean journal of nuclear medicine and molecular imaging2016
The role of active brown adipose tissue in human metabolism.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03875625 (Change of Adipose Tissues and Triglyceride in Obese Patients With Non-alcoholic Fatty Liver Disease After Bariatric Surgery or Life-style Intervention), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Change of Adipose Tissues and Triglyceride in Obese Patients With Non-alcoholic Fatty Liver Disease After Bariatric Surgery or Life-style Intervention
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Housing at 27 °C, a Near-Thermoneutral Temperature, Exacerbates Metabolic Dysfunction-Associated Steatohepatitis in C57BL/6J Mice.International journal of molecular sciences · 2026Article
- Alleviating Mechanism of Microencapsulated Compound Probiotics Against Obesity via PPAR Metabolic Pathway.Probiotics and antimicrobial proteins · 2026Article
- Associations between brown adipose tissue activity, serum lipid profiles, and cardiovascular events: insights from 18 F-fluorodeoxyglucose PET/computed tomography analysis.Nuclear medicine communications · 2025Article
- Thermoneutrality Inhibits Thermogenic Markers and Exacerbates Nonalcoholic Fatty Liver Disease in Mice.International journal of molecular sciences · 2024Article
- Indication of mixed glucose and fatty acid use by inferred brown adipose tissue activity in Samoans.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Association of PRDM16 rs12409277 and CtBP2 rs1561589 gene polymorphisms with lipid profile of adolescents.Archives of medical science : AMS · 2023Article
- The Role and Regulatory Mechanism of Brown Adipose Tissue Activation in Diet-Induced Thermogenesis in Health and Diseases.International journal of molecular sciences · 2022Review
- Green tea aqueous extract (GTAE) prevents high-fat diet-induced obesity by activating fat browning.Food science & nutrition · 2021Article
- Review
- Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota.Cell reports. Medicine · 2021Article
- Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype.Metabolism: clinical and experimental · 2021Article
- Hepatic steatosis is associated with abnormal hepatic enzymes, visceral adiposity, altered myocardial glucose uptake measured byBMC endocrine disorders · 2020Article
- Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice.The Journal of clinical investigation · 2019Article
- The association between diabetes mellitus and reduction in myocardial glucose uptake: a population-basedBMC cardiovascular disorders · 2018Article
- Brown and Beige Adipose Tissues in Health and Disease.Comprehensive Physiology · 2017Review
- Brown and Beige Adipose Tissue: Therapy for Obesity and Its Comorbidities?Endocrinology and metabolism clinics of North America · 2016Review
- The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults.Lipids in health and disease · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe presence of activated brown adipose tissue (ABAT) has been associated with a reduced risk of obesity in adults. We aimed to investigate whether the presence of ABAT in patients undergoing (18)F-FDG PET/CT examinations was related to blood lipid profiles, liver function, and the prevalence of non-alcoholic fatty liver disease (NAFLD).
methodsWe retrospectively and prospectively analysed the (18)F-FDG PET/CT scans from 5,907 consecutive patients who were referred to the Nuclear Medicine Department of the Marmara University School of Medicine from outpatient oncology clinics between July 2008 and June 2014 for a variety of diagnostic reasons. Attenuation coefficients for the liver and spleen were determined for at least five different areas. Blood samples were obtained before PET/CT to assess the blood lipid profiles and liver function.
resultsA total of 25 of the 5,907 screened individuals fulfilling the inclusion criteria for the study demonstrated brown fat tissue uptake [ABAT(+) subjects]. After adjustment for potential confounders, 75 individuals without evidence of ABAT on PET [ABAT(-) subjects] were enrolled for comparison purposes. The ABAT(+) group had lower total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, and aspartate transaminase levels (p < 0.01), whereas we found no significant differences in the serum triglyceride and high-density lipoprotein cholesterol levels between the two groups. The prevalence of NAFLD was significantly lower in ABAT(+) than in ABAT(-) subjects (p < 0.01).
conclusionOur study showed that the presence of ABAT in adults had a positive effect on their blood lipid profiles and liver function and was associated with reduced prevalence of NAFLD. Thus, our data suggest that activating brown adipose tissue may be a potential target for preventing and treating dyslipidaemia and NAFLD.
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