ArticleMalaria journal2015
Seasonality in malaria transmission: implications for case-management with long-acting artemisinin combination therapy in sub-Saharan Africa.
Article in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Agent-based models of malaria transmission: a systematic review.Malaria journal · 2018Pooled it
- Pharmacogenetics of artemether-lumefantrine influence on nevirapine disposition: Clinically significant drug-drug interaction?British journal of clinical pharmacology · 2019Trial
- Seasonal malaria chemoprevention in an area of extended seasonal transmission in Ashanti, Ghana: an individually randomised clinical trial.Tropical medicine & international health : TM & IH · 2016Trial
- Where and why malaria persists in heterogeneous transmission settings: insights from routine health facility data.BMJ global health · 2026Article
- Environmental factors influencing mosquito breeding and malaria transmission using geospatial technologies in the Wabi Shebele sub-basin, Ethiopia.Scientific reports · 2026Article
- Mathematical modeling of malaria vaccination with seasonality and immune feedback.PLoS computational biology · 2025Article
- "Man Who Won the War": Myth and Reality of Aldo Castellani's Role in Preserving the Health of Troops During the Italo-Ethiopian War 1935-1936.Advances in experimental medicine and biology · 2023Article
- The potential impact of Anopheles stephensi establishment on the transmission of Plasmodium falciparum in Ethiopia and prospective control measures.BMC medicine · 2022Article
- Risk of Plasmodium falciparum infection in south-west Burkina Faso: potential impact of expanding eligibility for seasonal malaria chemoprevention.Scientific reports · 2022Article
- Risk associations of submicroscopic malaria infection in lakeshore, plateau and highland areas of Kisumu County in western Kenya.PloS one · 2022Article
- Seasonality of confirmed malaria cases from 2008 to 2017 in Togo: a time series analysis by health district and target group.BMC infectious diseases · 2021Article
- Evaluation of different deployment strategies for larviciding to control malaria: a simulation study.Malaria journal · 2021Article
- Seasonality of agricultural exposure as an important predictor of seasonal yellow fever spillover in Brazil.Nature communications · 2021Article
- African genetic diversity and adaptation inform a precision medicine agenda.Nature reviews. Genetics · 2021Review
- Cost-effectiveness of district-wide seasonal malaria chemoprevention when implemented through routine malaria control programme in Kita, Mali using fixed point distribution.Malaria journal · 2021Article
- Evaluating the Performance of Malaria Genetics for Inferring Changes in Transmission Intensity Using Transmission Modeling.Molecular biology and evolution · 2021Article
- Practical Implications of a Relationship between Health Management Information System and Community Cohort-Based Malaria Incidence Rates.The American journal of tropical medicine and hygiene · 2020Article
- Effect of Free Healthcare Policy for Children under Five Years Old on the Incidence of Reported Malaria Cases in Burkina Faso by Bayesian Modelling: "Not only the Ears but also the Head of the Hippopotamus".International journal of environmental research and public health · 2020Article
- Impact of seasonal variations ineLife · 2019Article
- Using ante-natal clinic prevalence data to monitor temporal changes in malaria incidence in a humanitarian setting in the Democratic Republic of Congo.Malaria journal · 2018Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundLong-acting artemisinin-based combination therapy (LACT) offers the potential to prevent recurrent malaria attacks in highly exposed children. However, it is not clear where this advantage will be most important, and deployment of these drugs is not rationalized on this basis.
methodsTo understand where post-treatment prophylaxis would be most beneficial, the relationship between seasonality, transmission intensity and the interval between malaria episodes was explored using data from six cohort studies in West Africa and an individual-based malaria transmission model. The total number of recurrent malaria cases per 1000 child-years at risk, and the fraction of the total annual burden that this represents were estimated for sub-Saharan Africa.
resultsIn settings where prevalence is less than 10 %, repeat malaria episodes constitute a small fraction of the total burden, and few repeat episodes occur within the window of protection provided by currently available drugs. However, in higher transmission settings, and particularly in high transmission settings with highly seasonal transmission, repeat malaria becomes increasingly important, with up to 20 % of the total clinical burden in children estimated to be due to repeat episodes within 4 weeks of a prior attack.
conclusionAt a given level of transmission intensity and annual incidence, the concentration of repeat malaria episodes in time, and consequently the protection from LACT is highest in the most seasonal areas. As a result, the degree of seasonality, in addition to the overall intensity of transmission, should be considered by policy makers when deciding between ACT that differ in their duration of post-treatment prophylaxis.
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