ArticleInfection and immunity2015
MdsABC-Mediated Pathway for Pathogenicity in Salmonella enterica Serovar Typhimurium.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Beyond antibiotic resistance: evidence for resistance-nodulation-division (RND) efflux pumps as virulence determinants.Microbiology and molecular biology reviews : MMBR · 2025Review
- The molecular mechanisms of quinolone resistance in Salmonella: a review.Archives of microbiology · 2025Review
- The efflux pump SugE2 involved in protection of Salmonella 4,[5],12:i:- against quaternary ammonium salts and inhibition of virulence.PLoS pathogens · 2025Article
- First detection and genomic analysis ofFrontiers in veterinary science · 2025Article
- Added insult to injury? The response of meat-associated pathogens to proposed antimicrobial interventions.Applied microbiology and biotechnology · 2024Article
- Defense mechanisms ofFrontiers in antibiotics · 2024Review
- Drug resistance and physiological roles of RND multidrug efflux pumps inMicrobiology (Reading, England) · 2023Article
- Genomic Comparison of Eight Closed Genomes of Multidrug-ResistantFrontiers in microbiology · 2022Article
- RND Efflux Systems Contribute to Resistance and Virulence ofAntibiotics (Basel, Switzerland) · 2021Article
- Endoribonuclease-mediated control of hns mRNA stability constitutes a key regulatory pathway for Salmonella Typhimurium pathogenicity island 1 expression.PLoS pathogens · 2021Article
- Function and Inhibitory Mechanisms of Multidrug Efflux Pumps.Frontiers in microbiology · 2021Review
- Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance.PLoS pathogens · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MdsABC is a Salmonella-specific tripartite efflux pump that has been implicated in the virulence of Salmonella enterica serovar Typhimurium; however, little is known about the virulence factors associated with this pump. We observed MdsABC expression-dependent alterations in the degree of resistance to extracellular oxidative stress and macrophage-mediated killing. Thin-layer chromatography and tandem mass spectrometry analyses revealed that overexpression of MdsABC led to increased secretion of 1-palmitoyl-2-stearoyl-phosphatidylserine (PSPS), affecting the ability of the bacteria to invade and survive in host cells. Overexpression of MdsABC and external addition of PSPS similarly rendered the mdsABC deletion strain resistant to diamide. Diagonal gel analysis showed that PSPS treatment reduced the diamide-mediated formation of disulfide bonds, particularly in the membrane fraction of the bacteria. Salmonella infection of macrophages induced the upregulation of MdsABC expression and led to an increase of intracellular bacterial number and host cell death, similar to the effects of MdsABC overexpression and PSPS pretreatment on the mdsABC deletion strain. Our study shows that MdsABC mediates a previously uncharacterized pathway that involves PSPS as a key factor for the survival and virulence of S. Typhimurium in phagocytic cells.
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