ArticleEuropean journal of oral sciences2015
Genetic influences on dental enamel that impact caries differ between the primary and permanent dentitions.
Article in European journal of oral sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Association Between theGenetic testing and molecular biomarkers · 2021Pooled it
- Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis.BMC oral health · 2020Pooled it
- Mechanical Properties of Dental Enamel in Patients with Genetic Caries Susceptibility.International journal of molecular sciences · 2025Article
- Article
- Polymorphisms inThe Saudi dental journal · 2024Article
- AMELX and ENAM Polymorphisms and Dental Caries.International journal of dentistry · 2022Article
- Biomarkers for Lifetime Caries-Free Status.Journal of personalized medicine · 2020Article
- ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations.International journal of environmental research and public health · 2020Article
- Measuring the Microscopic Structures of Human Dental Enamel Can Predict Caries Experience.Journal of personalized medicine · 2020Article
- Importance of bicarbonate transport in pH control during amelogenesis - need for functional studies.Oral diseases · 2018Review
- Dental genetics in Brazil: Where we are.Molecular genetics & genomic medicine · 2018Article
- Consortium-based genome-wide meta-analysis for childhood dental caries traits.Human molecular genetics · 2018Article
- Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children.Clinical oral investigations · 2018Article
- The relationship between vitamin D receptor gene polymorphism and deciduous tooth decay in Chinese children.BMC oral health · 2017Article
- Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries.Journal of human genetics · 2017Article
- Variation in Enamel Formation Genes Influences Enamel DemineralizationFrontiers in physiology · 2017Article
- Enamel Research: Priorities and Future Directions.Frontiers in physiology · 2017Article
- Genes Involved in the Enamel Development Are Associated with Calcium and Phosphorus Level in Saliva.Caries research · 2017Article
- Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 3 countries.
Funding
Abstract
Clinically, primary and permanent teeth are distinct anatomically and the presentation of caries lesions differs between the two dentitions. Hence, the possibility exists that genetic contributions to tooth formation of the two dentitions are different. The purpose of this study was to test the hypothesis that genetic associations with an artificial caries model will not be the same between primary and permanent dentitions. Enamel samples from primary and permanent teeth were tested for microhardness at baseline, after carious lesion creation, and after fluoride application to verify association with genetic variants of selected genes. Associations were found between genetic variants of ameloblastin, amelogenin, enamelin, tuftelin, tuftelin interactive protein 11, and matrix metallopeptidase 20 and enamel from permanent teeth but not with enamel from primary teeth. In conclusion, our data continue to support that genetic variation may impact enamel development and consequently individual caries susceptibility. These effects may be distinct between primary and permanent dentitions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.