ArticleeLife2015
A shift in anterior-posterior positional information underlies the fin-to-limb evolution.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Evolution of limb and digit identity genes since the tetrapod ancestor.Nature communications · 2026Article
- Evolutionary pathway and genetic mechanisms of fin-to-limb transition in vertebrates.Frontiers in cell and developmental biology · 2026Review
- Caudal fin shape imprinted during late zebrafish embryogenesis is re-patterned by the Sonic hedgehog pathway.PLoS biology · 2025Article
- Article
- Anterior-posterior constraint on Hedgehog signaling by hhip in teleost fin elaboration.Development (Cambridge, England) · 2024Article
- Convergent Degenerated Regulatory Elements Associated with Limb Loss in Limbless Amphibians and Reptiles.Molecular biology and evolution · 2024Article
- The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development.Scientific reports · 2024Article
- De novo transcriptome for Chiloscyllium griseum, a long-tail carpet shark of the Indian waters.Scientific data · 2024Article
- Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates.Current biology : CB · 2021Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity.Nature communications · 2021Article
- Spiny and soft-rayed fin domains in acanthomorph fish are established through a BMP-Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Comparative genomic analysis of human GLI2 locus using slowly evolving fish revealed the ancestral gnathostome set of early developmental enhancers.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Article
- Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Sarcopterygian fin ontogeny elucidates the origin of hands with digits.Science advances · 2020Article
- Fin ray patterns at the fin-to-limb transition.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Attenuated Fgf Signaling Underlies the Forelimb Heterochrony in the Emu Dromaius novaehollandiae.Current biology : CB · 2019Article
- Evolution of the avian digital pattern.Scientific reports · 2019Article
- Cux2 refines the forelimb field by controlling expression ofBiology open · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pectoral fins of ancestral fishes had multiple proximal elements connected to their pectoral girdles. During the fin-to-limb transition, anterior proximal elements were lost and only the most posterior one remained as the humerus. Thus, we hypothesised that an evolutionary alteration occurred in the anterior-posterior (AP) patterning system of limb buds. In this study, we examined the pectoral fin development of catshark (Scyliorhinus canicula) and revealed that the AP positional values in fin buds are shifted more posteriorly than mouse limb buds. Furthermore, examination of Gli3 function and regulation shows that catshark fins lack a specific AP patterning mechanism, which restricts its expression to an anterior domain in tetrapods. Finally, experimental perturbation of AP patterning in catshark fin buds results in an expansion of posterior values and loss of anterior skeletal elements. Together, these results suggest that a key genetic event of the fin-to-limb transformation was alteration of the AP patterning network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.