ArticleJournal of experimental & clinical cancer research : CR2015
The efficacy of a photolyase-based device on the cancerization field: a clinical and thermographic study.
Article in Journal of experimental & clinical cancer research : CR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Effect of a Photolyase-Based Medical Device on Actinic Keratosis in Phototypes III-IV Patients: Real-Life Clinical Setting.Dermatology and therapy · 2025Article
- Understanding Active Photoprotection: DNA-Repair Enzymes and Antioxidants.Life (Basel, Switzerland) · 2024Review
- Photolyase Production and Current Applications: A Review.Molecules (Basel, Switzerland) · 2022Review
- DNA photolyase from Antarctic marine bacterium3 Biotech · 2021Article
- A Nobel-Winning Scientist: Aziz Sancar and the Impact of his Work on the Molecular Pathology of Neoplastic Diseases.Turk patoloji dergisi · 2021Review
- Use of a Topical Film-Forming Medical Device Containing RepairsomesClinical, cosmetic and investigational dermatology · 2020Article
- Review of Clinical Evidence over 10 Years on Prevention and Treatment of a Film-Forming Medical Device Containing Photolyase in the Management of Field Cancerization in Actinic Keratosis.Dermatology and therapy · 2019Review
- Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography.Oral oncology · 2019Article
- New Vision in Photoprotection and Photorepair.Dermatology and therapy · 2019Review
- Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects.Anais brasileiros de dermatologiaReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAt skin level, a cancerization field (CF) indicates some chronically photoexposed areas in which, besides a primary tumor, histological or biomolecular modifications without clinical signs are present. Active telethermography (ATT) allows us to observe the imaging of a hyperthermic halo (HH) surrounding the tumor . The Authors hypothesize HH as a possible expression of CF.
objectivesThe aim of this study were to verify whether HHs have the same histological or immunohistochemical characteristics as the CF and, secondly, to evaluate the efficacy of a device containing the enzyme photolyase in modifying thermographic parameters in these area.
methodsThe study included 30 patients affected by actinic keratosis, evaluated clinically and by ATT at time 0 and after 3, 6 and 9 months.
resultsThe ATT showed the presence of HHs in all the patients and, after the treatment, a significant modification of both the extension of these areas and the thermal parameters. In 5 patients for whom, while operated, two other biopsies were performed, respectively on the HH and on a perilesional non-hyperthermic area, in the HH, we detected a p53 and Ki 67 over-expression.
conclusionsOur results indicate that ATT could represent a useful paraclinic method in identifying CFs in subjects at risk.
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