Evidence map›Paper›PMID 26282715›Full record

GuidelineThe International journal on drug policy2015

Recommendations for the management of hepatitis C virus infection among people who inject drugs.

Jason Grebely, Geert Robaeys, Philip Bruggmann, Alessio Aghemo, Markus Backmund, Julie Bruneau, Jude Byrne, Olav Dalgard, Jordan J Feld, Margaret Hellard and 11 more

Open access · greenAbstract readPractice Guideline
In one paragraph

Guideline in The International journal on drug policy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 3 pooled it
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 3 syntheses or guidelines pooled it, 198 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. KASL clinical practice guidelines: management of hepatitis C.Clinical and molecular hepatology · 2016
    Guideline
  4. Trial
  5. Trial
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  8. Trial
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
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  17. In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022
    Article
  18. Article
  19. Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 18 institutions in 11 countries.

Jason GrebelyKirby Institute, UNSW Australia, Sydney, Australia. Electronic address: jgrebely@kirby.unsw.edu.au.
Geert RobaeysDepartment of Gastroenterology and Hepatology, Ziekenhuis Oost Limburg, Genk, Belgium; Department of Hepatology, UZ Leuven, Leuven, Belgium; Faculty of Medicine and Life Sciences, Limburg Clinical Research Program, Hasselt University, Hasselt, Belgium.
Philip BruggmannArud Centres of Addiction Medicine, Zurich, Switzerland.
Alessio AghemoA.M. Migliavacca Center for Liver Disease, Division of Gastroenterology and Hepatology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.
Markus BackmundLudwig-Maximilians-University, Munich, Germany; Praxiszentrum im Tal Munich, Munich, Germany.
Julie BruneauCRCHUM, Université de Montréal, Montreal, Canada.
Jude ByrneInternational Network of People who Use Drugs, Canberra, Australia.
Olav DalgardDepartment of Infectious Diseases, Akershus University Hospital, Lørenskog, Norway.
Jordan J FeldUniversity of Toronto, Toronto, Canada.
Margaret HellardBurnet Institute, Melbourne, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
Matthew HickmanSchool of Social & Community Medicine, University of Bristol, Bristol, United Kingdom.
Achim KautzEuropean Liver Patients Association, Cologne, Germany.
Alain LitwinDivision of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States.
Andrew R LloydInflammation and Infection Research Centre, School of Medical Sciences, UNSW Australia, Sydney, Australia.
Stefan MaussCenter for HIV and Hepatogastroenterology, Düsseldorf, Germany.
Maria PrinsDepartment of Research, Cluster Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands; Department of Internal Medicine, CINIMA, Academic Medical Centre, Amsterdam, The Netherlands.
Tracy SwanTreatment Action Group, New York, United States.
Martin SchaeferDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, Essen, Germany; Department of Psychiatry and Psychotherapy-CCM, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Lynn E TaylorDepartment of Medicine, Brown University, Providence, RI, United States.
Gregory J DoreKirby Institute, UNSW Australia, Sydney, Australia.
International Network for Hepatitis in Substance Users
Addiction Switzerland · CHAkershus University Hospital · NOAlbert Einstein College of Medicine · USAustralasian Society for HIV, Viral Hepatitis and Sexual Health Medicine · AUBrown University · USBurnet Institute · AUCenter for HIV and Hepatogastroenterology · DEGGD Amsterdam · NLKiryu University · JPKliniken Essen-Mitte · DEOrthopädische Praxis · DETreatment Action Group · USUniversitair Ziekenhuis Leuven · BEUniversité de Montréal · CAUniversity of Bristol · GBUniversity of Milan · ITUniversity of Toronto · CAUNSW Sydney · AU

Funding

Intensive Models of HCV Care for Injection Drug UsersR01DA034086 · NIDA · CLEMSON UNIVERSITY · PI LITWIN, ALAIN HARRIS · 2012 to 2016
$3.7M
Department of Health 12/136/105Department of Health RP-DG-0610-10055Medical Research Council MR/K023233/1NIDA NIH HHS R01 DA034086
6 · The paper itself

Abstract

In high income countries, the majority of new and existing hepatitis C virus (HCV) infections occur among people who inject drugs (PWID). In many low and middle income countries large HCV epidemics have also emerged among PWID populations. The burden of HCV-related liver disease among PWID is increasing, but treatment uptake remains extremely low. There are a number of barriers to care which should be considered and systematically addressed, but should not exclude PWID from HCV treatment. The rapid development of interferon-free direct-acting antiviral (DAA) therapy for HCV infection has brought considerable optimism to the HCV sector, with the realistic hope that therapeutic intervention will soon provide near optimal efficacy with well-tolerated, short duration, all oral regimens. Further, it has been clearly demonstrated that HCV treatment is safe and effective across a broad range of multidisciplinary healthcare settings. Given the burden of HCV-related disease among PWID, strategies to enhance HCV assessment and treatment in this group are urgently needed. These recommendations demonstrate that treatment among PWID is feasible and provide a framework for HCV assessment and care. Further research is needed to evaluate strategies to enhance testing, linkage to care, treatment, adherence, viral cure, and prevent HCV reinfection among PWID, particularly as new interferon-free DAA treatments for HCV infection become available.

Indexed as

Antiviral AgentsHepatitis CHumansSubstance Abuse, IntravenousAntiviral AgentsDrug usersGuidelinesHCVHIVInjectingInjectionPWID

Identifiers

PMID26282715
PMCPMC6130980
OpenAlexW2167150962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.