ArticleMolecular brain2015
The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood.
Article in Molecular brain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Recent Advances in the Molecular Mechanisms of Ocular Dominance Plasticity in the Visual Cortex.Neuroscience bulletin · 2025Review
- Non-invasive light flickering reinstates visual plasticity in adult mice via lipocalin 2.BMC biology · 2025Article
- High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7.Neuroscience bulletin · 2024Article
- Corticotropin releasing factor neurons in the visual cortex mediate long-term changes in visual function induced by early adversity.Neurobiology of stress · 2022Article
- Inhibition of Cdk5 in PV Neurons Reactivates Experience-Dependent Plasticity in Adult Visual Cortex.International journal of molecular sciences · 2021Article
- A sex-dependent delayed maturation of visual plasticity induced by adverse experiences in early childhood.Neurobiology of stress · 2020Article
- Genetic Difference of Hypothyroidism-Induced Cognitive Dysfunction in C57BL/6j and 129/Sv Mice.Neurochemical research · 2019Article
- Early Loss of Vision Results in Extensive Reorganization of Plasticity-Related Receptors and Alterations in Hippocampal Function That Extend Through Adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExperience-dependent plasticity is confined to the critical period of early postnatal life, and declines dramatically thereafter. This attenuation promotes the stabilization of cortical circuits, but also limits functional recovery of several brain diseases. The cognitive functions and synaptic plasticity in the hippocampus and prefrontal cortex are elevated following chronic magnesium treatment. Here, we explored the effect of magnesium treatment on visual plasticity and the potential clinical significance.
resultsVisual plasticity in adult mice was dramatically enhanced following magnesium treatment, which was concurrent with an increase in the expression of NR2 subunits of N-methyl-D-aspartate receptors. Blockade of NR2B activity in both the induction and expression periods of plasticity prevented this reinstatement. However, the plasticity restored via a decrease in cortical inhibition was independent on the activation of NR2B, indicating a different underlying mechanism. The functional excitatory synapses on layer 2/3 pyramidal neurons were increased following magnesium supplementation. Moreover, the synaptic and neuronal responses were reminiscent of that within the critical period, and this rejuvenation of adult visual cortex facilitated the recovery of visual functions in amblyopia.
conclusionsCollectively, our data reveal two distinct mechanisms underlying the restoration of visual plasticity in adulthood, and the rejuvenation of adult visual cortex following magnesium treatment provides a new avenue to develop clinical therapies for adult amblyopia, as well as to explore plasticity-based treatment of other brain diseases, such as stroke and aphasia.
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