Evidence map›Paper›PMID 26282631›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2015

Risk of Sex-Specific Cancers in Opposite-Sex and Same-Sex Twins in Denmark and Sweden.

Linda J Ahrenfeldt, Axel Skytthe, Sören Möller, Kamila Czene, Hans-Olov Adami, Lorelei A Mucci, Jaakko Kaprio, Inge Petersen, Kaare Christensen, Rune Lindahl-Jacobsen

Open access · greenAbstract readComparative StudyMulticenter StudyTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. The Danish Twin Registry: An Updated Overview.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Differences in Religiousness in Opposite-Sex and Same-Sex Twins in a Secular Society.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Linda J AhrenfeldtThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense C, Denmark. lahrenfeldt@health.sdu.dk.
Axel SkyttheThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense C, Denmark.
Sören MöllerThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense C, Denmark.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Lorelei A MucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Jaakko KaprioDepartment of Public Health and Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Inge PetersenThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense C, Denmark.
Kaare ChristensenThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense C, Denmark. Department of Clinical Biochemistry and Pharmacology and Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Rune Lindahl-JacobsenThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense C, Denmark. Max-Planck Odense Center on the Biodemography of Aging, University of Southern Denmark, Odense C, Denmark.
Karolinska Institutet · SE

Funding

TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROACH, DEBORAH A · 1990 to 2008
$17.5M
STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI SCOTT M. LYNCH · 2009 to 2026
$12.2M
THE RANGE OF MALE-FEMALE MORTALITY DIFFERENCESP01AG031719 · NIA · DUKE UNIVERSITY · PI ZENG, YI · 2009 to 2020
$10.2M
NIA NIH HHS P01 AG008761NIA NIH HHS P01 AG031719NIA NIH HHS P01-AG031719NIA NIH HHS P01-AG08761NIA NIH HHS P30 AG034424
6 · The paper itself

Abstract

backgroundIncreasing evidence shows that some cancers originate in utero. It is hypothesized that elevated exposure to some steroid hormones might increase cancer risk and that hormone transfer between twin fetuses could result in different prenatal exposure to testosterone.

methodsThis large-scale prospective twin study compared opposite-sex (OS) and same-sex (SS) twins to test the impact of intrauterine exposures on cancer risk. On the basis of the Danish and Swedish twin and cancer registries, we calculated incidence rate ratios for OS and SS twins, whereas standardized incidence ratios (SIR) with 95% confidence intervals (CI) were calculated for OS/SS twins compared with the general population.

resultsA total of 18,001 cancers were identified during 1943-2009. No significant differences were observed between OS and SS twins, neither for the sex-specific cancers nor for cancer at all sites. All-cause cancer was slightly reduced for OS and SS twins compared with the general population, significant for OS males (SIR, 0.95; 95% CI, 0.92-0.98) and for SS males and females (SIR, 0.97; 95% CI, 0.94-0.99).

conclusionsOur data suggest that having a male co-twin-which may entail higher exposure to prenatal testosterone-does not increase the risk of sex-specific cancers in OS females. Furthermore, the study supports that twinning per se is not a risk factor of cancer. IMPACT: Findings are reassuring, as they fail to provide evidence for the hypothesis that endocrine or other difference in the in utero milieu affects the risk of sex-specific cancers.

Indexed as

ForecastingTwins, DizygoticTwins, MonozygoticAdolescentAdultAgedChildChild, PreschoolDenmarkDiseases in TwinsFemaleHumansIncidenceInfantInfant, NewbornMale

Identifiers

PMID26282631
PMCPMC4782008
OpenAlexW2118534858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.