ArticleScientific reports2015
Reversible heart rhythm complexity impairment in patients with primary aldosteronism.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Temporal Changes in Nonlinear Heart Rate Variability Following Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation.Acta Cardiologica Sinica · 2026Article
- Aldosterone and the Broken Clock: Restoring Circadian Blood Pressure Rhythm in Primary Aldosteronism.Journal of the American Heart Association · 2026Article
- Heart rhythm complexity analysis in patients with inferior ST-elevation myocardial infarction.Scientific reports · 2023Article
- Real-time machine learning model to predict in-hospital cardiac arrest using heart rate variability in ICU.NPJ digital medicine · 2023Article
- Comparison of Heart Autonomic Control between Hemodynamically Stable and Unstable Patients during Hemodialysis Sessions: A Bayesian Approach.Entropy (Basel, Switzerland) · 2023Article
- The Value of Heart Rhythm Complexity in Identifying High-Risk Pulmonary Hypertension Patients.Entropy (Basel, Switzerland) · 2021Article
- Preoperative Heart Rate Variability During Sleep Predicts Vagus Nerve Stimulation Outcome Better in Patients With Drug-Resistant Epilepsy.Frontiers in neurology · 2021Article
- Impairment of Cardiac Autonomic Nerve Function in Pre-school Children With Intractable Epilepsy.Frontiers in neurology · 2021Article
- Heart rhythm complexity as predictors for the prognosis of end-stage renal disease patients undergoing hemodialysis.BMC nephrology · 2020Article
- Usefulness of heart rhythm complexity in heart failure detection and diagnosis.Scientific reports · 2020Article
- Heart Rhythm Complexity Predicts Long-Term Cardiovascular Outcomes in Peritoneal Dialysis Patients: A Prospective Cohort Study.Journal of the American Heart Association · 2020Article
- Alterations in heart-brain interactions under mild stress during a cognitive task are reflected in entropy of heart rate dynamics.Scientific reports · 2019Article
- Heart Rhythm Complexity Impairment in Patients with Pulmonary Hypertension.Scientific reports · 2019Article
- The association between heart rhythm complexity and the severity of abdominal aorta calcification in peritoneal dialysis patients.Scientific reports · 2018Article
- Preoperative Heart Rate Variability as Predictors of Vagus Nerve Stimulation Outcome in Patients with Drug-resistant Epilepsy.Scientific reports · 2018Article
- Serial heart rhythm complexity changes in patients with anterior wall ST segment elevation myocardial infarction.Scientific reports · 2017Article
- Probing the Fractal Pattern of Heartbeats in Drosophila Pupae by Visible Optical Recording System.Scientific reports · 2016Article
- Heart rhythm complexity impairment in patients undergoing peritoneal dialysis.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excess aldosterone secretion in patients with primary aldosteronism (PA) impairs their cardiovascular system. Heart rhythm complexity analysis, derived from heart rate variability (HRV), is a powerful tool to quantify the complex regulatory dynamics of human physiology. We prospectively analyzed 20 patients with aldosterone producing adenoma (APA) that underwent adrenalectomy and 25 patients with essential hypertension (EH). The heart rate data were analyzed by conventional HRV and heart rhythm complexity analysis including detrended fluctuation analysis (DFA) and multiscale entropy (MSE). We found APA patients had significantly decreased DFAα2 on DFA analysis and decreased area 1-5, area 6-15, and area 6-20 on MSE analysis (all p < 0.05). Area 1-5, area 6-15, area 6-20 in the MSE study correlated significantly with log-transformed renin activity and log-transformed aldosterone-renin ratio (all p < = 0.01). The conventional HRV parameters were comparable between PA and EH patients. After adrenalectomy, all the altered DFA and MSE parameters improved significantly (all p < 0.05). The conventional HRV parameters did not change. Our result suggested that heart rhythm complexity is impaired in APA patients and this is at least partially reversed by adrenalectomy.
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