Evidence map›Paper›PMID 26282492›Full record

Trial reportSpinal cord2016

Autologous bone marrow cell transplantation in acute spinal cord injury--an Indian pilot study.

H S Chhabra, K Sarda, M Arora, R Sharawat, V Singh, A Nanda, G M Sangodimath, V Tandon

Registry-linked trialOpen access · bronzeAbstract readClinical Trial, Phase IClinical Trial, Phase IIRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Spinal cord, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02260713 (Autologous Bone Marrow Cell Transplantation in Persons With Acute Spinal Cord Injury- An Indian Pilot Study), which is not on this map. Cited by 26 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 7 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02260713 phase1 / phase2completednot on this map

Autologous Bone Marrow Cell Transplantation in Persons With Acute Spinal Cord Injury- An Indian Pilot Study

TypeinterventionalSponsorIndian Spinal Injuries CentreRan2011 to 2017Enrolled21ConditionsAcute Spinal Cord InjuryArmsautologous bone marrow cell
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 7 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  8. [Advances in stem cell transplantation for traumatic spinal cord injury at different stages].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

H S ChhabraSpine Service, Indian Spinal Injuries Center, New Delhi, India.
K SardaSpine Service, Indian Spinal Injuries Center, New Delhi, India.
M AroraSpine Service, Indian Spinal Injuries Center, New Delhi, India.
R SharawatSpine Service, Indian Spinal Injuries Center, New Delhi, India.
V SinghSpine Service, Indian Spinal Injuries Center, New Delhi, India.
A NandaSpine Service, Indian Spinal Injuries Center, New Delhi, India.
G M SangodimathSpine Service, Indian Spinal Injuries Center, New Delhi, India.
V TandonSpine Service, Indian Spinal Injuries Center, New Delhi, India.
Indian Spinal Injuries Centre · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designPhase- I/II, prospective, randomized, single-blind, controlled pilot study. PRIMARY

objectiveTo determine the safety and feasibility of autologous bone marrow transplantation in patients with acute spinal cord injury (SCI) via two routes of transplantation as compared with controls.

settingIndian Spinal Injuries Center, New Delhi.

methodsTwenty-one subjects with acute, American Spinal Injury Association Impairment Scale (AIS) A (complete), traumatic SCI with neurological level T1-T12, were recruited and randomized into three groups of seven subjects each. Two groups underwent cell transplantation through the intrathecal or intralesional route, whereas the third served as control. Participants were assessed at baseline and followed up at 6 months and 12-months post enrollment. Safety and tolerability were evaluated by monitoring for any adverse events. Efficacy was assessed through neurological, functional and psychological evaluation, as well as through electrophysiological studies and urodynamics.

resultsSurgery was tolerated well by all participants. There were no significant adverse events attributable to the procedure. There was no significant improvement in the neurological, electrophysiological or urodynamic efficacy variables. A statistically significant improvement in functional scores as evaluated by the Spinal Cord Independence Measure and International Spinal Cord Injury Scale was observed in all groups.

conclusionsThe procedure is safe and feasible in AIS A participants with thoracic-level injuries at 12-months follow-up. No efficacy could be demonstrated that could be attributed to the procedure.

Indexed as

Treatment OutcomeAcute DiseaseAdolescentAdultBone Marrow TransplantationElectrophysiologyFemaleFollow-Up StudiesHumansIndiaMaleNeurologic ExaminationPilot ProjectsPsychological TestsRetrospective StudiesSpinal Cord Injuries

Identifiers

PMID26282492
OpenAlexW2407531026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.