Evidence map›Paper›PMID 26282458›Full record

ArticleJournal of cellular and molecular medicine2016

Transplantation of placenta-derived mesenchymal stem cells enhances angiogenesis after ischemic limb injury in mice.

Nanzi Xie, Zhihong Li, Timothy M Adesanya, Weixin Guo, Yang Liu, Minghuan Fu, Ahmet Kilic, Tao Tan, Hua Zhu, Xiaoyun Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  15. Review
  16. Mesenchymal Stem Cells Decrease M1/M2 Ratio and Alleviate Inflammation to Improve Limb Ischemia in Mice.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  17. Review
  18. Mesenchymal Stem Cell-Macrophage Choreography Supporting Spinal Cord Repair.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nanzi XieDivision of Geriatrics, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Zhihong LiDivision of General Surgery, Chenzhou First People's Hospital, Chenzhou, Hunan, China.
Timothy M AdesanyaDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Weixin GuoGuangdong Geriatrics Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yang LiuDivision of Geriatrics, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Minghuan FuDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Ahmet KilicDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Tao TanDivision of Geriatrics, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Hua ZhuDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Xiaoyun XieDivision of Geriatrics, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.

Funding

The Ohio State University Center for Clinical and Translational ScienceTL1TR001069 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$763k
NCATS NIH HHS TL1 TR001069
6 · The paper itself

Abstract

Mesenchymal stem cell-based therapy has emerged as a promising approach for the treatment of peripheral arterial disease. The purpose of this study was to examine the potential effects of human placenta-derived mesenchymal stem cells (PMSCs) on mouse hindlimb ischemia. PMSCs were isolated from human placenta tissue and characterized by flow cytometry. An in vivo surgical ligation-induced murine limb ischemia model was generated with fluorescent dye (CM-DiI) labelled PMSCs delivered via intramuscular injection. Our data show that PMSCs treatment significantly enhanced microvessel density, improved blood perfusion and diminished pathologies in ischemic mouse hindlimbs as compared to those in the control group. Further immunostaining studies suggested that injected PMSCs can incorporate into the vasculature and differentiate into endothelial and smooth muscle cells to enhance angiogenesis in ischemic hind limbs. This may in part explain the beneficial effects of PMSCs treatment. Taken together, we found that PMSCs treatment might be an effective treatment modality for treatment of ischemia-induced injury to mouse hind limbs by enhancement of angiogenesis.

Indexed as

Mesenchymal Stem Cell TransplantationNeovascularization, PhysiologicAnimalsCell DifferentiationCells, CulturedCytokinesEndothelial CellsFemaleHindlimbHumansIschemiaMaleMesenchymal Stem CellsMice, Inbred C57BLPlacentaPregnancyCytokinesangiogenesisischemiaparacrineplacentastem cells

Identifiers

PMID26282458
PMCPMC4717860

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.