ArticleNMR in biomedicine2015
Single-voxel (1)H spectroscopy in the human hippocampus at 3 T using the LASER sequence: characterization of neurochemical profile and reproducibility.
Article in NMR in biomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of sildenafil and calcitonin gene-related peptide on brainstem glutamate levels: a pharmacological proton magnetic resonance spectroscopy study at 3.0 T.The journal of headache and pain · 2018Trial
- Assessing the reliability of hippocampal single-voxel proton magnetic resonance spectroscopy through intra-class effect decomposition.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- From a Voxel to Maps: A Comparative Study of sLASER SVS and 3D-CRT-FID-MRSI at 3 T and 7 T.medRxiv : the preprint server for health sciences · 2025Article
- Reliability and Reproducibility of Metabolite Quantification UsingNMR in biomedicine · 2025Article
- Metabolic and Structural Alterations in the Motor System Following Spinal Cord Injury: An In-VivoJournal of neuroscience research · 2025Article
- Depression and the prefrontal-hippocampal pathway - A multimodal neuroimaging study in transgender women.Comprehensive psychoneuroendocrinology · 2025Article
- Article
- Magnetic resonance spectroscopy investigation in the right human hippocampus following spinal cord injury.Frontiers in neurology · 2023Article
- Reproducibility of 7-T brain spectroscopy using an ultrashort echo time STimulated Echo Acquisition Mode sequence and automated voxel repositioning.NMR in biomedicine · 2022Article
- Hippocampal single-voxel MR spectroscopy with a long echo time at 3 T using semi-LASER sequence.NMR in biomedicine · 2021Article
- On the reproducibility of hippocampal MEGA-sLASER GABA MRS at 7T using an optimized analysis pipeline.Magma (New York, N.Y.) · 2021Article
- Potential clinical impact of multiparametric quantitative MR spectroscopy in neurological disorders: A review and analysis.Magnetic resonance in medicine · 2020Review
- Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed byNeuroscience bulletin · 2020Article
- Hippocampal glutamate metabolites and glial activation in clinical high risk and first episode psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Comparison of reproducibility of single voxel spectroscopy and whole-brain magnetic resonance spectroscopy imaging at 3T.NMR in biomedicine · 2018Article
- Hippocampal metabolites in asthma and their implications for cognitive function.NeuroImage. Clinical · 2018Article
- Functional dynamics of hippocampal glutamate during associative learning assessed with in vivoNeuroImage · 2017Article
- Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex.NeuroImage · 2017Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
The hippocampus is crucial for long-term episodic memory and learning. It undergoes structural change in aging and is sensitive to neurodegenerative and psychiatric diseases. MRS studies have seldom been performed in the hippocampus due to technical challenges. The reproducibility of MRS in the hippocampus has not been evaluated at 3 T. The purpose of the present study was to quantify the concentration of metabolites in a small voxel placed in the hippocampus and evaluate the reproducibility of the quantification. Spectra were measured in a 2.4 mL voxel placed in the left hippocampus covering the body and most of the tail of the structure in 10 healthy subjects across three different sessions and quantified using LCModel. High-quality spectra were obtained, which allowed a reliable quantification of 10 metabolites including glutamate and glutamine. Reproducibility of MRS was evaluated with coefficient of variation, standard errors of measurement, and intraclass correlation coefficients. All of these measures showed improvement with increased number of averages. Changes of less than 5% in concentration of N-acetylaspartate, choline-containing compounds, and total creatine and of less than 10% in concentration of myo-inositol and the sum of glutamate and glutamine can be confidently detected between two measurements in a group of 20 subjects. A reliable and reproducible neurochemical profile of the human hippocampus was obtained using MRS at 3 T in a small hippocampal volume.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.