Evidence map›Paper›PMID 26282224›Full record

ArticleEnvironmental research2015

Residential proximity to major roadways and incident hypertension in post-menopausal women.

Samantha L Kingsley, Melissa N Eliot, Eric A Whitsel, Yi Wang, Brent A Coull, Lifang Hou, Helene G Margolis, Karen L Margolis, Lina Mu, Wen-Chih C Wu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Urban green spaces and mental health: Findings from Uganda.Hygiene and environmental health advances · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Samantha L KingsleyDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Melissa N EliotDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Eric A WhitselDepartment of Epidemiology, University of North Carolina Gillings School of Public Health, Chapel Hill, NC, USA.
Yi WangDepartment of Environmental Health Sciences, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA.
Brent A CoullDepartment of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
Lifang HouDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Helene G MargolisDepartment of Internal Medicine, School of Medicine, University of California, Davis, CA, USA.
Karen L MargolisHealth Partners Institute for Education and Research, Minneapolis, MN, USA.
Lina MuDepartment of Social and Preventive Medicine, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY, USA.
Wen-Chih C WuDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA; Providence Veterans Affairs Medical Center, Providence, RI, USA.
Karen C JohnsonDepartment of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Matthew A AllisonDepartment of Family and Preventive Medicine, University of California San Diego School of Medicine, San Diego, CA, USA.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Charles B EatonDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA; Memorial Hospital of Rhode Island, Pawtucket, RI, USA.
Gregory A WelleniusDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA. Electronic address: Gregory_wellenius@brown.edu.
Brown University · USBrigham and Women's Hospital · USHarvard University · USHealthPartners · USIndiana University – Purdue University Indianapolis · USNorthwestern University · USUniversity at Buffalo, State University of New York · USUniversity of California, Davis · USUniversity of California, San Diego · USUniversity of North Carolina at Chapel Hill · USUniversity of Tennessee Health Science Center · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Ambient Air Pollution and Incident StrokeR01ES020871 · NIEHS · BROWN UNIVERSITY · PI WELLENIUS, GREGORY A · 2012 to 2016
$2.7M
Mechanisms of Air Pollution Health Effects in Subjects with Heart FailureR00ES015774 · NIEHS · BROWN UNIVERSITY · PI WELLENIUS, GREGORY A · 2009 to 2011
$747k
NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIEHS NIH HHS P30 ES000002NIEHS NIH HHS R00 ES015774NIEHS NIH HHS R00-ES015774NIEHS NIH HHS R01 ES020871NIEHS NIH HHS R01-ES020871WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Living near major roadways has been associated with increased risk of cardiovascular morbidity and mortality, presumably from exposure to elevated levels of traffic-related air and/or noise pollution. This association may potentially be mediated through increased risk of incident hypertension, but results from prior studies are equivocal. Using Cox proportional hazards models we examined residential proximity to major roadways and incident hypertension among 38,360 participants of the Women's Health Initiative (WHI) Clinical Trial cohorts free of hypertension at enrollment and followed for a median of 7.9 years. Adjusting for participant demographics and lifestyle, trial participation, and markers of individual and neighborhood socioeconomic status, the hazard ratios for incident hypertension were 1.13 (95% CI: 1.00, 1.28), 1.03 (0.95, 1.11), 1.05 (0.99, 1.11), and 1.05 (1.00, 1.10) for participants living ≤50, >50-200, >200-400, and >400-1000 m vs >1000 m from the nearest major roadway, respectively (ptrend=0.013). This association varied substantially by WHI study region with hazard ratios for women living ≤50 m from a major roadway of 1.61 (1.18, 2.20) in the West, 1.51 (1.22, 1.87) in the Northeast, 0.89 (0.70, 1.14) in the South, and 0.94 (0.75, 1.19) in the Midwest. In this large, national cohort of post-menopausal women, residential proximity to major roadways was associated with incident hypertension in selected regions of the U.S. If causal, these results suggest residential proximity to major roadways, as a marker for air, noise and other traffic-related pollution, may be a risk factor for hypertension.

Indexed as

Air PollutantsPostmenopauseResidence CharacteristicsVehicle EmissionsAgedCohort StudiesEnvironmental MonitoringFemaleHumansHypertensionMiddle AgedNoise, TransportationProportional Hazards ModelsProspective StudiesUnited StatesAir PollutantsVehicle EmissionsAir pollutionBlood pressureHypertensionNoise pollutionTraffic pollutionWomen

Identifiers

PMID26282224
PMCPMC4609282
OpenAlexW1173228816

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.