Evidence map›Paper›PMID 26282186›Full record

ArticleThe Journal of physiology2015

Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training.

David Montero, Adrian Cathomen, Robert A Jacobs, Daniela Flück, Jeroen de Leur, Stefanie Keiser, Thomas Bonne, Niels Kirk, Anne-Kristine Lundby, Carsten Lundby

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 75 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 6 pooled it
35.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 6 syntheses or guidelines pooled it, 186 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Sex Dimorphism of VOSports medicine (Auckland, N.Z.) · 2019
    Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Exercise in the heat blunts improvements in aerobic power.European journal of applied physiology · 2021
    Trial
  14. Trial
  15. Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Trial
  16. Trial
  17. Trial
  18. Review
  19. Review
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

David MonteroZurich Centre for Integrative Human Physiology (ZIHP), University of Zurich, Institute of Physiology, Switzerland.
Adrian CathomenInstitute of Human Movement Sciences and Sport, ETH Zurich, Switzerland.
Robert A JacobsZurich Centre for Integrative Human Physiology (ZIHP), University of Zurich, Institute of Physiology, Switzerland.
Daniela FlückZurich Centre for Integrative Human Physiology (ZIHP), University of Zurich, Institute of Physiology, Switzerland.
Jeroen de LeurZurich Centre for Integrative Human Physiology (ZIHP), University of Zurich, Institute of Physiology, Switzerland.
Stefanie KeiserZurich Centre for Integrative Human Physiology (ZIHP), University of Zurich, Institute of Physiology, Switzerland.
Thomas BonneZurich Centre for Integrative Human Physiology (ZIHP), University of Zurich, Institute of Physiology, Switzerland.
Niels KirkZurich Centre for Integrative Human Physiology (ZIHP), University of Zurich, Institute of Physiology, Switzerland.
Anne-Kristine LundbyZurich Centre for Integrative Human Physiology (ZIHP), University of Zurich, Institute of Physiology, Switzerland.
Carsten LundbyZurich Centre for Integrative Human Physiology (ZIHP), University of Zurich, Institute of Physiology, Switzerland.
Swiss Integrative Center for Human Health · CHUniversity of Zurich · CHETH Zurich · CHWestern Carolina University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It remains unclear whether improvements in peak oxygen uptake (V̇(O2peak)) following endurance training (ET) are primarily determined by central and/or peripheral adaptations. Herein, we tested the hypothesis that the improvement in V̇(O2peak) following 6 weeks of ET is mainly determined by haematological rather than skeletal muscle adaptations. Sixteen untrained healthy male volunteers (age = 25 ± 4 years, V̇(O2peak) = 3.5 ± 0.5 l min(-1)) underwent supervised ET (6 weeks, 3-4 sessions per week). V̇(O2peak), peak cardiac output (Q̇(peak)), haemoglobin mass (Hb(mass)) and blood volumes were assessed prior to and following ET. Skeletal muscle biopsies were analysed for mitochondrial volume density (Mito(VD)), capillarity, fibre types and respiratory capacity (OXPHOS). After the post-ET assessment, red blood cell volume (RBCV) was re-established at the pre-ET level by phlebotomy and V̇(O2peak) and Q̇(peak) were measured again. We speculated that the contribution of skeletal muscle adaptations to the ET-induced increase in V̇(O2peak) would be revealed when controlling for haematological adaptations. V̇(O2peak) and Q̇(peak) were increased (P < 0.05) following ET (9 ± 8 and 7 ± 6%, respectively) and decreased (P < 0.05) after phlebotomy (-7 ± 7 and -10 ± 7%). RBCV, plasma volume and Hb(mass) all increased (P < 0.05) after ET (8 ± 4, 4 ± 6 and 6 ± 5%). As for skeletal muscle adaptations, capillary-to-fibre ratio and total Mito(VD) increased (P < 0.05) following ET (18 ± 16 and 43 ± 30%), but OXPHOS remained unaltered. Through stepwise multiple regression analysis, Q̇(peak), RBCV and Hb(mass) were found to be independent predictors of V̇(O2peak). In conclusion, the improvement in V̇(O2peak) following 6 weeks of ET is primarily attributed to increases in Q̇(peak) and oxygen-carrying capacity of blood in untrained healthy young subjects.

Indexed as

Adaptation, PhysiologicalAdultBlood VolumeExerciseHemoglobinsHexokinaseHumansL-Lactate DehydrogenaseMaleMitochondria, MuscleMuscle, SkeletalOxygen ConsumptionPhysical EnduranceYoung AdultHemoglobinsHexokinaseL-Lactate Dehydrogenase

Identifiers

PMID26282186
PMCPMC4606528
OpenAlexW1825636380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.