Evidence map›Paper›PMID 26282165›Full record

ArticleCancer research2015

STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma.

Jasmine Lau, Shirin Ilkhanizadeh, Susan Wang, Yekaterina A Miroshnikova, Nicolas A Salvatierra, Robyn A Wong, Christin Schmidt, Valerie M Weaver, William A Weiss, Anders I Persson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 90 citations in OpenAlex.

  1. Article
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  13. Glioblastoma Therapy: Past, Present and Future.International journal of molecular sciences · 2024
    Review
  14. Review
  15. Article
  16. Monocyte-neutrophil entanglement in glioblastoma.The Journal of clinical investigation · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jasmine LauDepartment of Pediatrics, University of California, San Francisco, San Francisco, California. Department of Neurology, Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, California. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California. Agency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore.
Shirin IlkhanizadehDepartment of Pediatrics, University of California, San Francisco, San Francisco, California. Department of Neurology, Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, California. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Susan WangDepartment of Neurology, Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, California. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California. Sandler Neurosciences Center, University of California, San Francisco, San Francisco, California.
Yekaterina A MiroshnikovaDepartment of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, California.
Nicolas A SalvatierraDepartment of Pediatrics, University of California, San Francisco, San Francisco, California. Department of Neurology, Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, California. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Robyn A WongDepartment of Pediatrics, University of California, San Francisco, San Francisco, California. Department of Neurology, Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, California. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Christin SchmidtDepartment of Pediatrics, University of California, San Francisco, San Francisco, California. Department of Neurology, Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, California. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Valerie M WeaverHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California. Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, California. Departments of Anatomy and Bioengineering and Therapeutic Sciences, and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California.
William A WeissDepartment of Pediatrics, University of California, San Francisco, San Francisco, California. Department of Neurology, Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, California. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California. anders.persson@ucsf.edu waweiss@gmail.com.
Anders I PerssonDepartment of Neurology, Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, California. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California. Sandler Neurosciences Center, University of California, San Francisco, San Francisco, California. anders.persson@ucsf.edu waweiss@gmail.com.
University of California, San Francisco · US

Funding

The vascular niche in glioma propagation and resistance to therapyU54CA163155 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BERGERS, GABRIELE, WEAVER, VALERIE MARIE · 2011 to 2015
$4.4M
Tension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9M
Antisecretory factor as a novel therapeutic agent in human glioblastomaR21NS088114 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERSSON, PER ANDERS INGEMAR · 2014 to 2015
$395k
Glycocalyx and NCOR2-Notch-Mediated Stemness in Glioblastoma AggressivenessF31CA180422 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIROSHNIKOVA, YEKATERINA ANDREEVNA · 2014 to 2015
$48k
NCI NIH HHS F31 CA180422NCI NIH HHS F31CA180422NCI NIH HHS R01 CA192914NCI NIH HHS U54 CA163155NCI NIH HHS U54CA163155NINDS NIH HHS R21 NS088114NINDS NIH HHS R21NS088114
6 · The paper itself

Abstract

High grade gliomas (HGG) are classified into four subgroups based on transcriptional signatures and phenotypic characteristics. In particular, the proneural-to-mesenchymal transition (PMT) is associated with increased malignancy, poor prognosis, and disease recurrence, but the underlying causes of PMT are still unclear. In this study, we investigated whether radiotherapy promotes PMT using a genetically engineered mouse model of proneural HGG. We found that cranial ionizing radiation induced robust and durable PMT in tumors. Additionally, we isolated primary proneural HGG cells from mouse and human tumors and demonstrate that radiation induced a sustained cell-intrinsic mesenchymal transition associated with increased invasiveness and resistance to the alkylating agent temozolomide. Expectedly, irradiation-induced PMT was also associated with activation of the STAT3 transcription factor, and the combination of STAT3 blockade using JAK2 inhibitors with radiation abrogated the mesenchymal transition and extended survival of mice. Taken together, our data suggest that clinical JAK2 inhibitors should be tested in conjunction with radiation in patients with proneural HGG as a new strategy for blocking the emergence of therapy-resistant mesenchymal tumors at relapse.

Indexed as

AllograftsAnimalsBiomarkersDisease Models, AnimalDisease ProgressionGene Expression Regulation, NeoplasticGliomaHumansJanus Kinase 2Mesenchymal Stem CellsMiceMice, KnockoutNeoplasm GradingNeoplastic Stem CellsRadiationSTAT3 Transcription FactorBiomarkersJanus Kinase 2STAT3 Transcription Factor

Identifiers

PMID26282165
PMCPMC4609277
OpenAlexW1911973956

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.