ArticleThe Journal of general virology2015
Variability and pathogenicity of hepatitis E virus genotype 3 variants.
Article in The Journal of general virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Genomic characterization and recombination analysis of hepatitis E virus in humans and swine across Asia: implications for food safety.Frontiers in microbiology · 2026Article
- Water-Based Epidemiological Investigation of Hepatitis E Virus in South Africa.Food and environmental virology · 2024Article
- Evidence of Circulation and Phylogenetic Analysis of Hepatitis E Virus (HEV) in Wild Boar in South-East Italy.Viruses · 2023Article
- Similarities, differences, and possible interactions between hepatitis E and hepatitis C viruses: Relevance for research and clinical practice.World journal of gastroenterology · 2022Review
- Effect of Hepatitis E Virus RNA Universal Blood Donor Screening, Catalonia, Spain, 2017‒2020.Emerging infectious diseases · 2022Article
- Identification and genetic diversity of hepatitis E virus in domestic swine from Slovakia.BMC veterinary research · 2021Article
- Comparison of Hepatitis E Virus Sequences from Humans and Swine, the Netherlands, 1998-2015.Viruses · 2021Article
- Update: proposed reference sequences for subtypes of hepatitis E virus (speciesThe Journal of general virology · 2020Article
- Specific circulating microRNAs during hepatitis E infection can serve as indicator for chronic hepatitis E.Scientific reports · 2020Article
- Classification of the Zoonotic Hepatitis E Virus Genotype 3 Into Distinct Subgenotypes.Frontiers in microbiology · 2020Article
- Hepatitis E virus in blood donors in England, 2016 to 2017: from selective to universal screening.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Probable transmission of hepatitis E virus (HEV) via transfusion in the United States.Transfusion · 2019Article
- Subtype-specific differences in the risk of hospitalisation among patients infected with hepatitis E virus genotype 3 in Belgium, 2010-2018.Epidemiology and infection · 2019Article
- Classification and Genomic Diversity of Enterically Transmitted Hepatitis Viruses.Cold Spring Harbor perspectives in medicine · 2018Review
- Hepatitis E: Still Waters Run Deep.Journal of clinical and translational hepatology · 2018Review
- Hepatitis E virus (HEV) in Scotland: evidence of recent increase in viral circulation in humans.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
- Origin and dispersal of Hepatitis E virus.Emerging microbes & infections · 2018Article
- Hepatitis E virus genotypes and subgenotypes causing acute hepatitis, Bulgaria, 2013-2015.PloS one · 2018Article
- Pork products associated with human infection caused by an emerging phylotype of hepatitis E virus in England and Wales.Epidemiology and infection · 2017Article
- Public health risks associated with hepatitis E virus (HEV) as a food-borne pathogen.EFSA journal. European Food Safety Authority · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Infection with hepatitis E virus (HEV) can be clinically inapparent or produce symptoms and signs of hepatitis of varying severity and occasional fatality. This variability in clinical outcomes may reflect differences in host susceptibility or the presence of virally encoded determinants of pathogenicity. Analysis of complete genome sequences supports the division of HEV genotype 3 (HEV-3) variants into three major clades: 3ra comprising HEV isolates from rabbits, and 3efg and 3abchij comprising the corresponding named subtypes derived from humans and pigs. Using this framework, we investigated associations between viral genetic variability of HEV-3 in symptomatic and asymptomatic infections by comparing HEV-3 subgenomic sequences previously obtained from blood donors with those from patients presenting with hepatitis in the UK (54 blood donors, 148 hepatitis patients), the Netherlands (38 blood donors, 119 hepatitis patients), France (24 blood donors, 55 hepatitis patients) and Germany (14 blood donors, 36 hepatitis patients). In none of these countries was evidence found for a significant association between virus variants and patient group (P>0.05 Fisher's exact test). Furthermore, within a group of 123 patients in Scotland with clinically apparent HEV infections, we found no evidence for an association between variants of HEV-3 and disease severity or alanine aminotransferase level. The lack of detectable virally encoded determinants of disease outcomes in HEV-3 infection implies a more important role for host factors in its clinical phenotype.
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