ArticleLab on a chip2015
A cost-effective fluorescence mini-microscope for biomedical applications.
Article in Lab on a chip, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 95 citations in OpenAlex.
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- A Modular Microfluidic Organoid Platform Using LEGO-Like Bricks.Advanced healthcare materials · 2024Article
- A Cell State Monitoring System with Integrated In Situ Imaging and pH Detection.Sensors (Basel, Switzerland) · 2023Article
- Implementation of miniaturized modular-array fluorescence microscopy for long-term live-cell imaging.Applied optics · 2023Article
- A Compact Control System to Enable Automated Operation of Microfluidic Bioanalytical Assays.Biosensors · 2022Article
- Cost-effective high-speed, three-dimensional live-cell imaging of HIV-1 transfer at the T cell virological synapse.iScience · 2022Article
- A Cost-Effective Nucleic Acid Detection System Using a Portable Microscopic Device.Micromachines · 2022Article
- MultipleXLab: A high-throughput portable live-imaging root phenotyping platform using deep learning and computer vision.Plant methods · 2022Article
- Low-cost and cleanroom-free prototyping of microfluidic and electrochemical biosensors: Techniques in fabrication and bioconjugation.Biomicrofluidics · 2021Review
- Picroscope: low-cost system for simultaneous longitudinal biological imaging.Communications biology · 2021Article
- Deep Learning-Enabled Resolution-Enhancement in Mini- and Regular Microscopy for Biomedical Imaging.Sensors and actuators. A, Physical · 2021Article
- Simultaneous Detection of Viability and Concentration of Microalgae Cells Based on Chlorophyll Fluorescence and Bright Field Dual Imaging.Micromachines · 2021Article
- High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology.Chemical reviews · 2021Review
- Miniaturized modular-array fluorescence microscopy.Biomedical optics express · 2020Article
- Low-cost calcium fluorometry for long-term nanoparticle studies in living cells.Scientific reports · 2020Article
- Sacrificial Bioprinting of a Mammary Ductal Carcinoma Model.Biotechnology journal · 2019Article
- Portable bright-field, fluorescence, and cross-polarized microscope toward point-of-care imaging diagnostics.Journal of biomedical optics · 2019Article
- Visualisation of dCas9 target search in vivo using an open-microscopy framework.Nature communications · 2019Article
- Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis toward Autonomous Decision-Making.ACS sensors · 2019Article
- Measuring and regulating oxygen levels in microphysiological systems: design, material, and sensor considerations.The Analyst · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 6 countries.
Funding
Abstract
We have designed and fabricated a miniature microscope from off-the-shelf components and a webcam, with built-in fluorescence capability for biomedical applications. The mini-microscope was able to detect both biochemical parameters, such as cell/tissue viability (e.g. live/dead assay), and biophysical properties of the microenvironment such as oxygen levels in microfabricated tissues based on an oxygen-sensitive fluorescent dye. This mini-microscope has adjustable magnifications from 8-60×, achieves a resolution as high as <2 μm, and possesses a long working distance of 4.5 mm (at a magnification of 8×). The mini-microscope was able to chronologically monitor cell migration and analyze beating of microfluidic liver and cardiac bioreactors in real time, respectively. The mini-microscope system is cheap, and its modularity allows convenient integration with a wide variety of pre-existing platforms including, but not limited to, cell culture plates, microfluidic devices, and organs-on-a-chip systems. Therefore, we envision its widespread application in cell biology, tissue engineering, biosensing, microfluidics, and organs-on-chips, which can potentially replace conventional bench-top microscopy where long-term in situ and large-scale imaging/analysis is required.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.